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Role of bile salt in regulating Mcl-1 phosphorylation and chemoresistance in hepatocellular carcinoma cells

BACKGROUND: Glycochenodeoxycholate (GCDA) is one of the major human bile salts. Bile salts stimulate cell survival and proliferation through the mitogen-activated protein kinase, but the downstream signaling mechanism(s) remains enigmatic. Mcl-1 is an antiapoptotic molecule of the Bcl2 family that i...

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Detalles Bibliográficos
Autores principales:	Liao, Mingmei, Zhao, Jinfeng, Wang, Ton, Duan, Jinghua, Zhang, Yangde, Deng, Xingming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3107804/ https://www.ncbi.nlm.nih.gov/pubmed/21507240 http://dx.doi.org/10.1186/1476-4598-10-44

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