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Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission

Alpha-synuclein aggregation plays a central role in Parkinson's disease pathology. Direct transmission of alpha-synuclein from pathologically affected to healthy unaffected neurons may be important in the anatomical spread of the disease through the nervous system. We have demonstrated that exo...

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Detalles Bibliográficos
Autores principales:	Alvarez-Erviti, Lydia, Seow, Yiqi, Schapira, Anthony H., Gardiner, Chris, Sargent, Ian L., Wood, Matthew J.A., Cooper, J. Mark
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Academic Press 2011
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3107939/ https://www.ncbi.nlm.nih.gov/pubmed/21303699 http://dx.doi.org/10.1016/j.nbd.2011.01.029

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