Generation of Pathogenic Th17 Cells in the Absence of TGF-β Signaling

CD4(+) T cells that selectively produce interleukin (IL)-17, are critical for host defense and autoimmunity(1–4). Crucial for T helper17 (Th17) cells in vivo(5,6), IL-23 has been thought to be incapable of driving initial differentiation. Rather, IL-6 and transforming growth factor (TGF)-β1 have bee...

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Detalles Bibliográficos
Autores principales: Ghoreschi, Kamran, Laurence, Arian, Yang, Xiang-Ping, Tato, Cristina M., McGeachy, Mandy J., Konkel, Joanne, Ramos, Haydeé L., Wei, Lai, Davidson, Todd, Bouladoux, Nicolas, Grainger, John, Chen, Qian, Kanno, Yuka, Watford, Wendy T., Sun, Hong-Wei, Eberl, Gérard, Shevach, Ethan, Belkaid, Yasmine, Cua, Daniel J., Chen, Wanjun, O’Shea, John J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3108066/
https://www.ncbi.nlm.nih.gov/pubmed/20962846
http://dx.doi.org/10.1038/nature09447

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