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Cross-Sectional Analysis of the Utility of Pulmonary Function Tests in Predicting Emphysema in Ever-Smokers
Emphysema is largely an under-diagnosed medical condition that can exist in smokers in the absence of airway obstruction. We aimed to determine the sensitivity and specificity of pulmonary function tests (PFTs) in assessing emphysema using quantitative CT scans as the reference standard. We enrolled...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Molecular Diversity Preservation International (MDPI)
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3108112/ https://www.ncbi.nlm.nih.gov/pubmed/21655122 http://dx.doi.org/10.3390/ijerph8051324 |
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author | Hesselbacher, Sean E. Ross, Robert Schabath, Matthew B. Smith, E. O’Brian Perusich, Sarah Barrow, Nadia Smithwick, Pamela Mammen, Manoj J. Coxson, Harvey Krowchuk, Natasha Corry, David B. Kheradmand, Farrah |
author_facet | Hesselbacher, Sean E. Ross, Robert Schabath, Matthew B. Smith, E. O’Brian Perusich, Sarah Barrow, Nadia Smithwick, Pamela Mammen, Manoj J. Coxson, Harvey Krowchuk, Natasha Corry, David B. Kheradmand, Farrah |
author_sort | Hesselbacher, Sean E. |
collection | PubMed |
description | Emphysema is largely an under-diagnosed medical condition that can exist in smokers in the absence of airway obstruction. We aimed to determine the sensitivity and specificity of pulmonary function tests (PFTs) in assessing emphysema using quantitative CT scans as the reference standard. We enrolled 224 ever-smokers (current or former) over the age of 40. CT of thorax was used to quantify the low attenuation area (% emphysema), and to measure the standardized airway wall thickness. PFTs were used individually and in combination to predict their ability to discriminate radiographic emphysema. Significant emphysema (>7%) was detected in 122 (54%) subjects. Twenty six (21%) emphysema subjects had no evidence of airflow obstruction (FEV(1)/FVC ratio <70%), while all subjects with >23% emphysema showed airflow obstruction. The sensitivity and specificity of spirometry for detecting radiographic emphysema were 79% and 75%, respectively. Standardized airway wall thickness was increased in subjects with airflow obstruction, but did not correlate with emphysema severity. In this cohort of lifetime ever-smokers, PFTs alone were inadequate for diagnosing emphysema. Airway wall thickness quantified by CT morphometry was associated with airflow limitation, but not with emphysema indicating that the heterogeneous nature of lung disease in smokers may represent distinct phenotypes. |
format | Online Article Text |
id | pubmed-3108112 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Molecular Diversity Preservation International (MDPI) |
record_format | MEDLINE/PubMed |
spelling | pubmed-31081122011-06-08 Cross-Sectional Analysis of the Utility of Pulmonary Function Tests in Predicting Emphysema in Ever-Smokers Hesselbacher, Sean E. Ross, Robert Schabath, Matthew B. Smith, E. O’Brian Perusich, Sarah Barrow, Nadia Smithwick, Pamela Mammen, Manoj J. Coxson, Harvey Krowchuk, Natasha Corry, David B. Kheradmand, Farrah Int J Environ Res Public Health Article Emphysema is largely an under-diagnosed medical condition that can exist in smokers in the absence of airway obstruction. We aimed to determine the sensitivity and specificity of pulmonary function tests (PFTs) in assessing emphysema using quantitative CT scans as the reference standard. We enrolled 224 ever-smokers (current or former) over the age of 40. CT of thorax was used to quantify the low attenuation area (% emphysema), and to measure the standardized airway wall thickness. PFTs were used individually and in combination to predict their ability to discriminate radiographic emphysema. Significant emphysema (>7%) was detected in 122 (54%) subjects. Twenty six (21%) emphysema subjects had no evidence of airflow obstruction (FEV(1)/FVC ratio <70%), while all subjects with >23% emphysema showed airflow obstruction. The sensitivity and specificity of spirometry for detecting radiographic emphysema were 79% and 75%, respectively. Standardized airway wall thickness was increased in subjects with airflow obstruction, but did not correlate with emphysema severity. In this cohort of lifetime ever-smokers, PFTs alone were inadequate for diagnosing emphysema. Airway wall thickness quantified by CT morphometry was associated with airflow limitation, but not with emphysema indicating that the heterogeneous nature of lung disease in smokers may represent distinct phenotypes. Molecular Diversity Preservation International (MDPI) 2011-05 2011-04-29 /pmc/articles/PMC3108112/ /pubmed/21655122 http://dx.doi.org/10.3390/ijerph8051324 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Article Hesselbacher, Sean E. Ross, Robert Schabath, Matthew B. Smith, E. O’Brian Perusich, Sarah Barrow, Nadia Smithwick, Pamela Mammen, Manoj J. Coxson, Harvey Krowchuk, Natasha Corry, David B. Kheradmand, Farrah Cross-Sectional Analysis of the Utility of Pulmonary Function Tests in Predicting Emphysema in Ever-Smokers |
title | Cross-Sectional Analysis of the Utility of Pulmonary Function Tests in Predicting Emphysema in Ever-Smokers |
title_full | Cross-Sectional Analysis of the Utility of Pulmonary Function Tests in Predicting Emphysema in Ever-Smokers |
title_fullStr | Cross-Sectional Analysis of the Utility of Pulmonary Function Tests in Predicting Emphysema in Ever-Smokers |
title_full_unstemmed | Cross-Sectional Analysis of the Utility of Pulmonary Function Tests in Predicting Emphysema in Ever-Smokers |
title_short | Cross-Sectional Analysis of the Utility of Pulmonary Function Tests in Predicting Emphysema in Ever-Smokers |
title_sort | cross-sectional analysis of the utility of pulmonary function tests in predicting emphysema in ever-smokers |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3108112/ https://www.ncbi.nlm.nih.gov/pubmed/21655122 http://dx.doi.org/10.3390/ijerph8051324 |
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