Cargando…
The Comparative Protective Effects of Ganoderma Spores Lipid and Fish Oil on N-Methyl-N-Nitrosourea-Induced Photoreceptor Cell Lesion in Rats
Purpose. To compare Ganoderma spores lipid (GSL) and fish oil (FO) in inhibiting retinal photoreceptor cell lesions induced by N-methyl-N-nitrosourea (MNU) in rats. Methods. 120 rats were untreated (normal control, NC group) or treated with a single intraperitoneal injection of 40 mg/kg MNU (MNU gro...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2011
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3108162/ https://www.ncbi.nlm.nih.gov/pubmed/21660315 http://dx.doi.org/10.1155/2011/903261 |
_version_ | 1782205279670108160 |
---|---|
author | Gao, Yang Deng, Xin-Guo Li, Na Luo, Guang-Wei Chung, Peter C. K. |
author_facet | Gao, Yang Deng, Xin-Guo Li, Na Luo, Guang-Wei Chung, Peter C. K. |
author_sort | Gao, Yang |
collection | PubMed |
description | Purpose. To compare Ganoderma spores lipid (GSL) and fish oil (FO) in inhibiting retinal photoreceptor cell lesions induced by N-methyl-N-nitrosourea (MNU) in rats. Methods. 120 rats were untreated (normal control, NC group) or treated with a single intraperitoneal injection of 40 mg/kg MNU (MNU group) then treated with GSL (GSL group) or FO (FO group). Eyes were obtained at 1, 3, 5, 7, and 10 days. Results. Light microscopy assay demonstrated that GSL and FO alleviated rat retinal photoreceptor cell damage (GSL and FO versus MNU group P < .001) similarly (GSL versus FO group P = .980). Electron microscopy confirmed that GSL and FO reversed damage to photoreceptor segments and photoreceptor cell nuclei. GSL-treated rats showed significantly elevated a-wave and b-wave amplitudes over MNU group (P < .05) but less than NC group (P < .05) and not significantly different from FO group (P > .05). Conclusion. GSL, like FO, alleviates rat retinal photoreceptor cell damage induced by MNU. |
format | Online Article Text |
id | pubmed-3108162 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-31081622011-06-09 The Comparative Protective Effects of Ganoderma Spores Lipid and Fish Oil on N-Methyl-N-Nitrosourea-Induced Photoreceptor Cell Lesion in Rats Gao, Yang Deng, Xin-Guo Li, Na Luo, Guang-Wei Chung, Peter C. K. Evid Based Complement Alternat Med Research Article Purpose. To compare Ganoderma spores lipid (GSL) and fish oil (FO) in inhibiting retinal photoreceptor cell lesions induced by N-methyl-N-nitrosourea (MNU) in rats. Methods. 120 rats were untreated (normal control, NC group) or treated with a single intraperitoneal injection of 40 mg/kg MNU (MNU group) then treated with GSL (GSL group) or FO (FO group). Eyes were obtained at 1, 3, 5, 7, and 10 days. Results. Light microscopy assay demonstrated that GSL and FO alleviated rat retinal photoreceptor cell damage (GSL and FO versus MNU group P < .001) similarly (GSL versus FO group P = .980). Electron microscopy confirmed that GSL and FO reversed damage to photoreceptor segments and photoreceptor cell nuclei. GSL-treated rats showed significantly elevated a-wave and b-wave amplitudes over MNU group (P < .05) but less than NC group (P < .05) and not significantly different from FO group (P > .05). Conclusion. GSL, like FO, alleviates rat retinal photoreceptor cell damage induced by MNU. Hindawi Publishing Corporation 2011 2011-04-17 /pmc/articles/PMC3108162/ /pubmed/21660315 http://dx.doi.org/10.1155/2011/903261 Text en Copyright © 2011 Yang Gao et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Gao, Yang Deng, Xin-Guo Li, Na Luo, Guang-Wei Chung, Peter C. K. The Comparative Protective Effects of Ganoderma Spores Lipid and Fish Oil on N-Methyl-N-Nitrosourea-Induced Photoreceptor Cell Lesion in Rats |
title | The Comparative Protective Effects of Ganoderma Spores Lipid and Fish Oil on N-Methyl-N-Nitrosourea-Induced Photoreceptor Cell Lesion in Rats |
title_full | The Comparative Protective Effects of Ganoderma Spores Lipid and Fish Oil on N-Methyl-N-Nitrosourea-Induced Photoreceptor Cell Lesion in Rats |
title_fullStr | The Comparative Protective Effects of Ganoderma Spores Lipid and Fish Oil on N-Methyl-N-Nitrosourea-Induced Photoreceptor Cell Lesion in Rats |
title_full_unstemmed | The Comparative Protective Effects of Ganoderma Spores Lipid and Fish Oil on N-Methyl-N-Nitrosourea-Induced Photoreceptor Cell Lesion in Rats |
title_short | The Comparative Protective Effects of Ganoderma Spores Lipid and Fish Oil on N-Methyl-N-Nitrosourea-Induced Photoreceptor Cell Lesion in Rats |
title_sort | comparative protective effects of ganoderma spores lipid and fish oil on n-methyl-n-nitrosourea-induced photoreceptor cell lesion in rats |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3108162/ https://www.ncbi.nlm.nih.gov/pubmed/21660315 http://dx.doi.org/10.1155/2011/903261 |
work_keys_str_mv | AT gaoyang thecomparativeprotectiveeffectsofganodermasporeslipidandfishoilonnmethylnnitrosoureainducedphotoreceptorcelllesioninrats AT dengxinguo thecomparativeprotectiveeffectsofganodermasporeslipidandfishoilonnmethylnnitrosoureainducedphotoreceptorcelllesioninrats AT lina thecomparativeprotectiveeffectsofganodermasporeslipidandfishoilonnmethylnnitrosoureainducedphotoreceptorcelllesioninrats AT luoguangwei thecomparativeprotectiveeffectsofganodermasporeslipidandfishoilonnmethylnnitrosoureainducedphotoreceptorcelllesioninrats AT chungpeterck thecomparativeprotectiveeffectsofganodermasporeslipidandfishoilonnmethylnnitrosoureainducedphotoreceptorcelllesioninrats AT gaoyang comparativeprotectiveeffectsofganodermasporeslipidandfishoilonnmethylnnitrosoureainducedphotoreceptorcelllesioninrats AT dengxinguo comparativeprotectiveeffectsofganodermasporeslipidandfishoilonnmethylnnitrosoureainducedphotoreceptorcelllesioninrats AT lina comparativeprotectiveeffectsofganodermasporeslipidandfishoilonnmethylnnitrosoureainducedphotoreceptorcelllesioninrats AT luoguangwei comparativeprotectiveeffectsofganodermasporeslipidandfishoilonnmethylnnitrosoureainducedphotoreceptorcelllesioninrats AT chungpeterck comparativeprotectiveeffectsofganodermasporeslipidandfishoilonnmethylnnitrosoureainducedphotoreceptorcelllesioninrats |