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Genetic and Functional Diversity of Pseudomonas aeruginosa Lipopolysaccharide

Lipopolysccharide (LPS) is an integral component of the Pseudomonas aeruginosa cell envelope, occupying the outer leaflet of the outer membrane in this Gram-negative opportunistic pathogen. It is important for bacterium–host interactions and has been shown to be a major virulence factor for this org...

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Autores principales: Lam, Joseph S., Taylor, Véronique L., Islam, Salim T., Hao, Youai, Kocíncová, Dana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3108286/
https://www.ncbi.nlm.nih.gov/pubmed/21687428
http://dx.doi.org/10.3389/fmicb.2011.00118
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author Lam, Joseph S.
Taylor, Véronique L.
Islam, Salim T.
Hao, Youai
Kocíncová, Dana
author_facet Lam, Joseph S.
Taylor, Véronique L.
Islam, Salim T.
Hao, Youai
Kocíncová, Dana
author_sort Lam, Joseph S.
collection PubMed
description Lipopolysccharide (LPS) is an integral component of the Pseudomonas aeruginosa cell envelope, occupying the outer leaflet of the outer membrane in this Gram-negative opportunistic pathogen. It is important for bacterium–host interactions and has been shown to be a major virulence factor for this organism. Structurally, P. aeruginosa LPS is composed of three domains, namely, lipid A, core oligosaccharide, and the distal O antigen (O-Ag). Most P. aeruginosa strains produce two distinct forms of O-Ag, one a homopolymer of D-rhamnose that is a common polysaccharide antigen (CPA, formerly termed A band), and the other a heteropolymer of three to five distinct (and often unique dideoxy) sugars in its repeat units, known as O-specific antigen (OSA, formerly termed B band). Compositional differences in the O units among the OSA from different strains form the basis of the International Antigenic Typing Scheme for classification via serotyping of different strains of P. aeruginosa. The focus of this review is to provide state-of-the-art knowledge on the genetic and resultant functional diversity of LPS produced by P. aeruginosa. The underlying factors contributing to this diversity will be thoroughly discussed and presented in the context of its contributions to host–pathogen interactions and the control/prevention of infection.
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spelling pubmed-31082862011-06-16 Genetic and Functional Diversity of Pseudomonas aeruginosa Lipopolysaccharide Lam, Joseph S. Taylor, Véronique L. Islam, Salim T. Hao, Youai Kocíncová, Dana Front Microbiol Microbiology Lipopolysccharide (LPS) is an integral component of the Pseudomonas aeruginosa cell envelope, occupying the outer leaflet of the outer membrane in this Gram-negative opportunistic pathogen. It is important for bacterium–host interactions and has been shown to be a major virulence factor for this organism. Structurally, P. aeruginosa LPS is composed of three domains, namely, lipid A, core oligosaccharide, and the distal O antigen (O-Ag). Most P. aeruginosa strains produce two distinct forms of O-Ag, one a homopolymer of D-rhamnose that is a common polysaccharide antigen (CPA, formerly termed A band), and the other a heteropolymer of three to five distinct (and often unique dideoxy) sugars in its repeat units, known as O-specific antigen (OSA, formerly termed B band). Compositional differences in the O units among the OSA from different strains form the basis of the International Antigenic Typing Scheme for classification via serotyping of different strains of P. aeruginosa. The focus of this review is to provide state-of-the-art knowledge on the genetic and resultant functional diversity of LPS produced by P. aeruginosa. The underlying factors contributing to this diversity will be thoroughly discussed and presented in the context of its contributions to host–pathogen interactions and the control/prevention of infection. Frontiers Research Foundation 2011-06-01 /pmc/articles/PMC3108286/ /pubmed/21687428 http://dx.doi.org/10.3389/fmicb.2011.00118 Text en Copyright © 2011 Lam, Taylor, Islam, Hao and Kocíncová. http://www.frontiersin.org/licenseagreement This is an open-access article subject to a non-exclusive license between the authors and Frontiers Media SA, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and other Frontiers conditions are complied with.
spellingShingle Microbiology
Lam, Joseph S.
Taylor, Véronique L.
Islam, Salim T.
Hao, Youai
Kocíncová, Dana
Genetic and Functional Diversity of Pseudomonas aeruginosa Lipopolysaccharide
title Genetic and Functional Diversity of Pseudomonas aeruginosa Lipopolysaccharide
title_full Genetic and Functional Diversity of Pseudomonas aeruginosa Lipopolysaccharide
title_fullStr Genetic and Functional Diversity of Pseudomonas aeruginosa Lipopolysaccharide
title_full_unstemmed Genetic and Functional Diversity of Pseudomonas aeruginosa Lipopolysaccharide
title_short Genetic and Functional Diversity of Pseudomonas aeruginosa Lipopolysaccharide
title_sort genetic and functional diversity of pseudomonas aeruginosa lipopolysaccharide
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3108286/
https://www.ncbi.nlm.nih.gov/pubmed/21687428
http://dx.doi.org/10.3389/fmicb.2011.00118
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