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Genetic Polymorphism of Cancer Susceptibility Genes and HPV Infection in Cervical Carcinogenesis
It is widely accepted that specific human papillomavirus (HPV) types are the central etiologic agent of cervical carcinogenesis. However, a number of infected women do not develop invasive lesions, suggesting that other environmental and host factors may play decisive roles in the persistence of HPV...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE-Hindawi Access to Research
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3108378/ https://www.ncbi.nlm.nih.gov/pubmed/21660264 http://dx.doi.org/10.4061/2011/364069 |
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author | Nunobiki, Osamu Ueda, Masatsugu Toji, Eisaku Yamamoto, Michiko Akashi, Kyoko Sato, Naomi Izuma, Shinji Torii, Kiyo Tanaka, Ichiro Okamoto, Yoshiaki Noda, Sadamu |
author_facet | Nunobiki, Osamu Ueda, Masatsugu Toji, Eisaku Yamamoto, Michiko Akashi, Kyoko Sato, Naomi Izuma, Shinji Torii, Kiyo Tanaka, Ichiro Okamoto, Yoshiaki Noda, Sadamu |
author_sort | Nunobiki, Osamu |
collection | PubMed |
description | It is widely accepted that specific human papillomavirus (HPV) types are the central etiologic agent of cervical carcinogenesis. However, a number of infected women do not develop invasive lesions, suggesting that other environmental and host factors may play decisive roles in the persistence of HPV infection and further malignant conversion of cervical epithelium. Although many previous reports have focused on HPV and environmental factors, the role of host susceptibility to cervical carcinogenesis is largely unknown. Here, we review the findings of genetic association studies in cervical carcinogenesis with special reference to polymorphisms of glutathione-S-transferase (GST) isoforms, p53 codon 72, murine double-minute 2 homolog (MDM2) gene promoter 309, and FAS gene promoter -670 together with HPV types including our recent research results. |
format | Online Article Text |
id | pubmed-3108378 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | SAGE-Hindawi Access to Research |
record_format | MEDLINE/PubMed |
spelling | pubmed-31083782011-06-09 Genetic Polymorphism of Cancer Susceptibility Genes and HPV Infection in Cervical Carcinogenesis Nunobiki, Osamu Ueda, Masatsugu Toji, Eisaku Yamamoto, Michiko Akashi, Kyoko Sato, Naomi Izuma, Shinji Torii, Kiyo Tanaka, Ichiro Okamoto, Yoshiaki Noda, Sadamu Patholog Res Int Review Article It is widely accepted that specific human papillomavirus (HPV) types are the central etiologic agent of cervical carcinogenesis. However, a number of infected women do not develop invasive lesions, suggesting that other environmental and host factors may play decisive roles in the persistence of HPV infection and further malignant conversion of cervical epithelium. Although many previous reports have focused on HPV and environmental factors, the role of host susceptibility to cervical carcinogenesis is largely unknown. Here, we review the findings of genetic association studies in cervical carcinogenesis with special reference to polymorphisms of glutathione-S-transferase (GST) isoforms, p53 codon 72, murine double-minute 2 homolog (MDM2) gene promoter 309, and FAS gene promoter -670 together with HPV types including our recent research results. SAGE-Hindawi Access to Research 2011-05-31 /pmc/articles/PMC3108378/ /pubmed/21660264 http://dx.doi.org/10.4061/2011/364069 Text en Copyright © 2011 Osamu Nunobiki et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Nunobiki, Osamu Ueda, Masatsugu Toji, Eisaku Yamamoto, Michiko Akashi, Kyoko Sato, Naomi Izuma, Shinji Torii, Kiyo Tanaka, Ichiro Okamoto, Yoshiaki Noda, Sadamu Genetic Polymorphism of Cancer Susceptibility Genes and HPV Infection in Cervical Carcinogenesis |
title | Genetic Polymorphism of Cancer Susceptibility Genes and HPV Infection in Cervical Carcinogenesis |
title_full | Genetic Polymorphism of Cancer Susceptibility Genes and HPV Infection in Cervical Carcinogenesis |
title_fullStr | Genetic Polymorphism of Cancer Susceptibility Genes and HPV Infection in Cervical Carcinogenesis |
title_full_unstemmed | Genetic Polymorphism of Cancer Susceptibility Genes and HPV Infection in Cervical Carcinogenesis |
title_short | Genetic Polymorphism of Cancer Susceptibility Genes and HPV Infection in Cervical Carcinogenesis |
title_sort | genetic polymorphism of cancer susceptibility genes and hpv infection in cervical carcinogenesis |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3108378/ https://www.ncbi.nlm.nih.gov/pubmed/21660264 http://dx.doi.org/10.4061/2011/364069 |
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