Synthesis and Antibacterial Activity of Pentacyclines: A Novel Class of Tetracycline Analogs

[Image: see text] Employing a highly efficient total synthesis approach, we synthesized and evaluated for antibacterial activity diverse and novel pentacycline analogs with systematic variations at C7, C8, C9, and C10. Certain substitution groups, as well as substitution patterns at various position...

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Detalles Bibliográficos
Autores principales: Sun, Cuixiang, Hunt, Diana K., Clark, Roger B., Lofland, Denene, O’Brien, William J., Plamondon, Louis, Xiao, Xiao-Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2011
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3108469/
https://www.ncbi.nlm.nih.gov/pubmed/21500832
http://dx.doi.org/10.1021/jm1015395

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