Cargando…

Cystic Fibrosis: A New Target for 4-Imidazo[2,1-b]thiazole-1,4-dihydropyridines

[Image: see text] The pharmacology of the cystic fibrosis transmembrane conductance regulator (CFTR) Cl(–) channel has attracted significant interest in recent years with the aim to search for rational new therapies for diseases caused by CFTR malfunction. Mutations that abolish the function of CFTR...

Descripción completa

Detalles Bibliográficos
Autores principales:	Budriesi, Roberta, Ioan, Pierfranco, Leoni, Alberto, Pedemonte, Nicoletta, Locatelli, Alessandra, Micucci, Matteo, Chiarini, Alberto, Galietta, Luis J. V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2011
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3108470/ https://www.ncbi.nlm.nih.gov/pubmed/21568323 http://dx.doi.org/10.1021/jm200199r

Ejemplares similares

Cardiovascular Profile of Xanthone-Based 1,4 Dihydropyridines Bearing a Lidoflazine Pharmacophore Fragment
por: Bisi, Alessandra, et al.
Publicado: (2018)

Synthesis of 3-(Imidazo[2,1-b]thiazol-6-yl)-2H-chromen-2-one Derivatives and Study of Their Antiviral Activity against Parvovirus B19
por: Conti, Ilaria, et al.
Publicado: (2019)

Design, synthesis and biological evaluation of benzo-[d]-imidazo-[2,1-b]-thiazole and imidazo-[2,1-b]-thiazole carboxamide triazole derivatives as antimycobacterial agents
por: Chitti, Surendar, et al.
Publicado: (2022)

6-(4-Chlorophenyl)-3-methylimidazo[2,1-b]thiazole
por: Bunev, Alexander S., et al.
Publicado: (2013)

Imidazo[2,1-b]thiazole-Coupled Natural Noscapine Derivatives as Anticancer Agents
por: Nagireddy, Praveen Kumar Reddy, et al.
Publicado: (2019)

Sweet Chestnut (Castanea sativa Mill.) Bark Extract: Cardiovascular Activity and Myocyte Protection against Oxidative Damage
por: Chiarini, Alberto, et al.
Publicado: (2013)

Design and synthesis of novel Imidazo[2,1-b]thiazole derivatives as potent antiviral and antimycobacterial agents
por: Gürsoy, Elif, et al.
Publicado: (2020)

Intracellular and in vivo evaluation of imidazo[2,1-b]thiazole-5-carboxamide anti-tuberculosis compounds
por: Moraski, Garrett C., et al.
Publicado: (2020)

Convenient Synthesis of Thiohydantoins, Imidazole-2-thiones and Imidazo[2,1-b]thiazol-4-iums from Polymer-Supported α-Acylamino Ketones
por: Králová, Petra, et al.
Publicado: (2018)

N-(3-Oxo-1-thia-4-azaspiro[4.5]dec-4-yl)-6-phenylimidazo[2,1-b][1,3]thiazole-3-acetamide hemihydrate
por: Akkurt, Mehmet, et al.
Publicado: (2008)

Design, Synthesis and Biological Evaluation of New Imidazo[2,1-b]Thiazole Derivatives as Selective COX-2 Inhibitors
por: Shahrasbi, Mahsa, et al.
Publicado: (2018)

Fluorinated Derivatives of Benz[4,5]imidazo[1,2-b][1,3] thiazole—Inhibitors of Reproduction of Measles Virus
por: Pokrovskii, A. G., et al.
Publicado: (2004)

2-[6-(4-Chlorophenyl)imidazo[2,1-b][1,3]thiazol-2-yl]-N′-[(E)-4-methoxybenzylidene]acetohydrazide
por: Akkurt, Mehmet, et al.
Publicado: (2010)

3-Aryl-4-nitrobenzothiochromans S,S-dioxide: From Calcium-Channel Modulators Properties to Multidrug-Resistance Reverting Activity
por: Micucci, Matteo, et al.
Publicado: (2020)

Synthesis and Biological Evaluation of Imidazo[2,1-b]Thiazole based Sulfonyl Piperazines as Novel Carbonic Anhydrase II Inhibitors
por: Manasa, Kesari Lakshmi, et al.
Publicado: (2020)

Curcuma longa Extract Exerts a Myorelaxant Effect on the Ileum and Colon in a Mouse Experimental Colitis Model, Independent of the Anti-Inflammatory Effect
por: Aldini, Rita, et al.
Publicado: (2012)

Olive Leaves and Hibiscus Flowers Extracts-Based Preparation Protect Brain from Oxidative Stress-Induced Injury
por: Chiaino, Elda, et al.
Publicado: (2020)

Synthesis, Characterization, and Biological Activity of a Novel Series of Benzo[4,5]imidazo[2,1-b]thiazole Derivatives as Potential Epidermal Growth Factor Receptor Inhibitors
por: Deng, Xinshan, et al.
Publicado: (2019)

2-(4-Fluorophenyl)-N-{4-[6-(4-fluorophenyl)-2,3-dihydroimidazo[2,1-b][1,3]thiazol-5-yl]pyridin-2-yl}acetamide
por: Selig, Roland, et al.
Publicado: (2010)

Comparison between 1,2-Dihydropyridine and 1,4-Dihydropyridine on Hydride-Donating Ability and Activity
por: Zhang, Jin-Ye, et al.
Publicado: (2022)

Synthesis and Antibacterial Activities of Novel Imidazo[2,1-b]-1,3,4-thiadiazoles
por: Atta, Kamal F. M., et al.
Publicado: (2011)

Playing with Opening and Closing of Heterocycles: Using the Cusmano-Ruccia Reaction to Develop a Novel Class of Oxadiazolothiazinones, Active as Calcium Channel Modulators and P-Glycoprotein Inhibitors
por: Spinelli, Domenico, et al.
Publicado: (2014)

Synthesis, Molecular Docking Screening and Anti-Proliferative Potency Evaluation of Some New Imidazo[2,1-b]Thiazole Linked Thiadiazole Conjugates
por: Rashdan, Huda R. M., et al.
Publicado: (2020)

7-Benzyl-3-methyl-6-phenylimidazo[2,1-b][1,3]thiazol-7-ium chloride 0.75-hydrate
por: Guo-Li, Huang, et al.
Publicado: (2013)

Apoptotic-Induced Effects of Acacia Catechu Willd. Extract in Human Colon Cancer Cells
por: Chiaino, Elda, et al.
Publicado: (2020)

2-Isobutyl-6-phenylimidazo[2,1-b][1,3,4]thiadiazole
por: Fun, Hoong-Kun, et al.
Publicado: (2011)

8H-Chromeno[2′,3′:4,5]imidazo[2,1-a]isoquinoline
por: Safarov, Saifidin, et al.
Publicado: (2010)

6-(4-Chlorophenyl)-2-isobutylimidazo[2,1-b][1,3,4]thiadiazole
por: Fun, Hoong-Kun, et al.
Publicado: (2010)

Intramolecular hydrogen bonds in 1,4-dihydropyridine derivatives
por: Petrova, M., et al.
Publicado: (2018)

6-(3-Chlorophenyl)imidazo[2,1-b][1,3,4]thiadiazole
por: Praveen, A.S., et al.
Publicado: (2012)

Synthesis, Structural Characterization, and Cytotoxic Activity of New Benzo[d]imidazo[2,1-b]thiazole Derivatives Against MCF-7 Breast Cancer Cells
por: Ahmadi, Nahid, et al.
Publicado: (2022)

2-Isobutyl-6-(4-methoxyphenyl)imidazo[2,1-b][1,3,4]thiadiazole
por: Fun, Hoong-Kun, et al.
Publicado: (2011)

6-(4-Bromophenyl)-2-(4-fluorobenzyl)imidazo[2,1-b][1,3,4]thiadiazole
por: Banu, Afshan, et al.
Publicado: (2011)

Pharmacological Correctors of Mutant CFTR Mistrafficking
por: Pedemonte, Nicoletta, et al.
Publicado: (2012)

Synthesis, Antifungal and Antitumor Activity of Novel (Z)-5-Hetarylmethylidene-1,3-thiazol-4-ones and (Z)-5-Ethylidene-1,3-thiazol-4-ones
por: Insuasty, Alberto, et al.
Publicado: (2013)

On water catalyst-free synthesis of benzo[d]imidazo[2,1-b] thiazoles and novel N-alkylated 2-aminobenzo[d]oxazoles under microwave irradiation
por: Mukku, Narasimharao, et al.
Publicado: (2020)

An isoxazole strategy for the synthesis of 4-oxo-1,4-dihydropyridine-3-carboxylates
por: Zanakhov, Timur O, et al.
Publicado: (2022)

Correction to ‘Intramolecular hydrogen bonds in 1,4-dihydropyridine derivatives’
por: Petrova, M., et al.
Publicado: (2018)

Direct Aminolysis of Ethoxycarbonylmethyl 1,4-Dihydropyridine-3-carboxylates
por: Vigante, Brigita, et al.
Publicado: (2015)

1,4-Dihydropyridine: synthetic advances, medicinal and insecticidal properties
por: A., Parthiban, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_vbue801iofc0nprimk63s5sr5h