Beneficial Effects of Anisodamine in Shock Involved Cholinergic Anti-Inflammatory Pathway

Anisodamine, an antagonist of muscarinic receptor, has been used therapeutically to improve blood flow in circulatory disorders such as septic shock in China since 1965. The main mechanism of anisodamine for anti-shock proposed in Pharmacology for Chinese medical students is to improve blood flow in...

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Autores principales: Zhao, Ting, Li, Dong-Jie, Liu, Chong, Su, Ding-Feng, Shen, Fu-Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2011
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3108475/
https://www.ncbi.nlm.nih.gov/pubmed/21687515
http://dx.doi.org/10.3389/fphar.2011.00023
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author Zhao, Ting
Li, Dong-Jie
Liu, Chong
Su, Ding-Feng
Shen, Fu-Ming
author_facet Zhao, Ting
Li, Dong-Jie
Liu, Chong
Su, Ding-Feng
Shen, Fu-Ming
author_sort Zhao, Ting
collection PubMed
description Anisodamine, an antagonist of muscarinic receptor, has been used therapeutically to improve blood flow in circulatory disorders such as septic shock in China since 1965. The main mechanism of anisodamine for anti-shock proposed in Pharmacology for Chinese medical students is to improve blood flow in the microcirculation. Here, we suggest a new mechanism for its anti-shock effect. That is, anisodamine, by blocking muscarinic receptor, results in rerouting of acetylcholine to α7 nicotinic acetylcholine receptor (α7nAChR) bringing about increased acetylcholine-mediated activation of α7nAChR and the cholinergic anti-inflammatory pathway.
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spelling pubmed-31084752011-06-16 Beneficial Effects of Anisodamine in Shock Involved Cholinergic Anti-Inflammatory Pathway Zhao, Ting Li, Dong-Jie Liu, Chong Su, Ding-Feng Shen, Fu-Ming Front Pharmacol Pharmacology Anisodamine, an antagonist of muscarinic receptor, has been used therapeutically to improve blood flow in circulatory disorders such as septic shock in China since 1965. The main mechanism of anisodamine for anti-shock proposed in Pharmacology for Chinese medical students is to improve blood flow in the microcirculation. Here, we suggest a new mechanism for its anti-shock effect. That is, anisodamine, by blocking muscarinic receptor, results in rerouting of acetylcholine to α7 nicotinic acetylcholine receptor (α7nAChR) bringing about increased acetylcholine-mediated activation of α7nAChR and the cholinergic anti-inflammatory pathway. Frontiers Research Foundation 2011-05-02 /pmc/articles/PMC3108475/ /pubmed/21687515 http://dx.doi.org/10.3389/fphar.2011.00023 Text en Copyright © 2011 Zhao, Li, Liu, Su and Shen. http://www.frontiersin.org/licenseagreement This is an open-access article subject to a non-exclusive license between the authors and Frontiers Media SA, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and other Frontiers conditions are complied with.
spellingShingle Pharmacology
Zhao, Ting
Li, Dong-Jie
Liu, Chong
Su, Ding-Feng
Shen, Fu-Ming
Beneficial Effects of Anisodamine in Shock Involved Cholinergic Anti-Inflammatory Pathway
title Beneficial Effects of Anisodamine in Shock Involved Cholinergic Anti-Inflammatory Pathway
title_full Beneficial Effects of Anisodamine in Shock Involved Cholinergic Anti-Inflammatory Pathway
title_fullStr Beneficial Effects of Anisodamine in Shock Involved Cholinergic Anti-Inflammatory Pathway
title_full_unstemmed Beneficial Effects of Anisodamine in Shock Involved Cholinergic Anti-Inflammatory Pathway
title_short Beneficial Effects of Anisodamine in Shock Involved Cholinergic Anti-Inflammatory Pathway
title_sort beneficial effects of anisodamine in shock involved cholinergic anti-inflammatory pathway
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3108475/
https://www.ncbi.nlm.nih.gov/pubmed/21687515
http://dx.doi.org/10.3389/fphar.2011.00023
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