Selectivity and Specificity of Sphingosine 1-Phosphate Receptor Ligands: “Off-Targets” or Complex Pharmacology?

A recent perspective published in Frontiers of Pharmacology by Salomone and Waeber (2011) discussed the selectivity and specificity of sphingosine 1-phosphate (S1P) receptor ligands. This perspective surveyed the use of various S1P receptor ligands and attempted to reconcile a number of inconsistenc...

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Autores principales: Pyne, Nigel J., Pyne, Susan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2011
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3108476/
https://www.ncbi.nlm.nih.gov/pubmed/21687518
http://dx.doi.org/10.3389/fphar.2011.00026
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author Pyne, Nigel J.
Pyne, Susan
author_facet Pyne, Nigel J.
Pyne, Susan
author_sort Pyne, Nigel J.
collection PubMed
description A recent perspective published in Frontiers of Pharmacology by Salomone and Waeber (2011) discussed the selectivity and specificity of sphingosine 1-phosphate (S1P) receptor ligands. This perspective surveyed the use of various S1P receptor ligands and attempted to reconcile a number of inconsistencies in the predicted biological outcomes: these were interpreted as “off-target” effects. Therefore the perspective cautioned against the use of these S1P receptor ligands. Here we highlight the complex pharmacology of S1P receptors, which along with “inside-out” signaling might provide an alternative explanation for “off-target” effects.
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spelling pubmed-31084762011-06-16 Selectivity and Specificity of Sphingosine 1-Phosphate Receptor Ligands: “Off-Targets” or Complex Pharmacology? Pyne, Nigel J. Pyne, Susan Front Pharmacol Pharmacology A recent perspective published in Frontiers of Pharmacology by Salomone and Waeber (2011) discussed the selectivity and specificity of sphingosine 1-phosphate (S1P) receptor ligands. This perspective surveyed the use of various S1P receptor ligands and attempted to reconcile a number of inconsistencies in the predicted biological outcomes: these were interpreted as “off-target” effects. Therefore the perspective cautioned against the use of these S1P receptor ligands. Here we highlight the complex pharmacology of S1P receptors, which along with “inside-out” signaling might provide an alternative explanation for “off-target” effects. Frontiers Research Foundation 2011-05-31 /pmc/articles/PMC3108476/ /pubmed/21687518 http://dx.doi.org/10.3389/fphar.2011.00026 Text en Copyright © 2011 Pyne and Pyne. http://www.frontiersin.org/licenseagreement This is an open-access article subject to a non-exclusive license between the authors and Frontiers Media SA, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and other Frontiers conditions are complied with.
spellingShingle Pharmacology
Pyne, Nigel J.
Pyne, Susan
Selectivity and Specificity of Sphingosine 1-Phosphate Receptor Ligands: “Off-Targets” or Complex Pharmacology?
title Selectivity and Specificity of Sphingosine 1-Phosphate Receptor Ligands: “Off-Targets” or Complex Pharmacology?
title_full Selectivity and Specificity of Sphingosine 1-Phosphate Receptor Ligands: “Off-Targets” or Complex Pharmacology?
title_fullStr Selectivity and Specificity of Sphingosine 1-Phosphate Receptor Ligands: “Off-Targets” or Complex Pharmacology?
title_full_unstemmed Selectivity and Specificity of Sphingosine 1-Phosphate Receptor Ligands: “Off-Targets” or Complex Pharmacology?
title_short Selectivity and Specificity of Sphingosine 1-Phosphate Receptor Ligands: “Off-Targets” or Complex Pharmacology?
title_sort selectivity and specificity of sphingosine 1-phosphate receptor ligands: “off-targets” or complex pharmacology?
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3108476/
https://www.ncbi.nlm.nih.gov/pubmed/21687518
http://dx.doi.org/10.3389/fphar.2011.00026
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