CUTANEOUS DRUG HYPERSENSITIVITY: IMMUNOLOGICAL AND GENETIC PERSPECTIVE

Drug hypersensitivity is an unpredictable, immunologically mediated adverse reaction, clustered in a genetically predisposed individual. The role of “hapten concept” in immune sensitization has recently been contested by the “pharmacological interaction” hypothesis. After completion of the “human ge...

Descripción completa

Detalles Bibliográficos
Autores principales: Ghosh, Kisalay, Banerjee, Gautam, Ghosal, Asok Kumar, Nandi, Jayoti
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications 2011
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3108509/
https://www.ncbi.nlm.nih.gov/pubmed/21716938
http://dx.doi.org/10.4103/0019-5154.80402
_version_ 1782205318410797056
author Ghosh, Kisalay
Banerjee, Gautam
Ghosal, Asok Kumar
Nandi, Jayoti
author_facet Ghosh, Kisalay
Banerjee, Gautam
Ghosal, Asok Kumar
Nandi, Jayoti
author_sort Ghosh, Kisalay
collection PubMed
description Drug hypersensitivity is an unpredictable, immunologically mediated adverse reaction, clustered in a genetically predisposed individual. The role of “hapten concept” in immune sensitization has recently been contested by the “pharmacological interaction” hypothesis. After completion of the “human genome project” and with the availability of high-resolution genotyping, genetic susceptibility to hypersensitivity for certain drugs has been proved beyond doubt though the trend is ethnicity and phenotype dependent. Application of this newly acquired knowledge may reduce or abolish the morbidity and mortality associated with cutaneous drug hypersensitivity.
format Online
Article
Text
id pubmed-3108509
institution National Center for Biotechnology Information
language English
publishDate 2011
publisher Medknow Publications
record_format MEDLINE/PubMed
spelling pubmed-31085092011-06-28 CUTANEOUS DRUG HYPERSENSITIVITY: IMMUNOLOGICAL AND GENETIC PERSPECTIVE Ghosh, Kisalay Banerjee, Gautam Ghosal, Asok Kumar Nandi, Jayoti Indian J Dermatol Review Article Drug hypersensitivity is an unpredictable, immunologically mediated adverse reaction, clustered in a genetically predisposed individual. The role of “hapten concept” in immune sensitization has recently been contested by the “pharmacological interaction” hypothesis. After completion of the “human genome project” and with the availability of high-resolution genotyping, genetic susceptibility to hypersensitivity for certain drugs has been proved beyond doubt though the trend is ethnicity and phenotype dependent. Application of this newly acquired knowledge may reduce or abolish the morbidity and mortality associated with cutaneous drug hypersensitivity. Medknow Publications 2011 /pmc/articles/PMC3108509/ /pubmed/21716938 http://dx.doi.org/10.4103/0019-5154.80402 Text en © Indian Journal of Dermatology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Ghosh, Kisalay
Banerjee, Gautam
Ghosal, Asok Kumar
Nandi, Jayoti
CUTANEOUS DRUG HYPERSENSITIVITY: IMMUNOLOGICAL AND GENETIC PERSPECTIVE
title CUTANEOUS DRUG HYPERSENSITIVITY: IMMUNOLOGICAL AND GENETIC PERSPECTIVE
title_full CUTANEOUS DRUG HYPERSENSITIVITY: IMMUNOLOGICAL AND GENETIC PERSPECTIVE
title_fullStr CUTANEOUS DRUG HYPERSENSITIVITY: IMMUNOLOGICAL AND GENETIC PERSPECTIVE
title_full_unstemmed CUTANEOUS DRUG HYPERSENSITIVITY: IMMUNOLOGICAL AND GENETIC PERSPECTIVE
title_short CUTANEOUS DRUG HYPERSENSITIVITY: IMMUNOLOGICAL AND GENETIC PERSPECTIVE
title_sort cutaneous drug hypersensitivity: immunological and genetic perspective
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3108509/
https://www.ncbi.nlm.nih.gov/pubmed/21716938
http://dx.doi.org/10.4103/0019-5154.80402
work_keys_str_mv AT ghoshkisalay cutaneousdrughypersensitivityimmunologicalandgeneticperspective
AT banerjeegautam cutaneousdrughypersensitivityimmunologicalandgeneticperspective
AT ghosalasokkumar cutaneousdrughypersensitivityimmunologicalandgeneticperspective
AT nandijayoti cutaneousdrughypersensitivityimmunologicalandgeneticperspective

Ejemplares similares