Strain- and Sex-Dependent Circadian Changes in Abcc2 Transporter Expression: Implications for Irinotecan Chronotolerance in Mouse Ileum

BACKGROUND: ATP-binding cassette transporter abcc2 is involved in the cellular efflux of irinotecan. The drug is toxic for mouse ileum, where abcc2 is highly expressed. Here, we investigate whether circadian changes in local abcc2 expression participate in the circadian rhythm of irinotecan toxicity...

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Detalles Bibliográficos
Autores principales: Okyar, Alper, Piccolo, Enza, Ahowesso, Constance, Filipski, Elisabeth, Hossard, Virginie, Guettier, Catherine, La Sorda, Rosanna, Tinari, Nicola, Iacobelli, Stefano, Lévi, Francis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3108586/
https://www.ncbi.nlm.nih.gov/pubmed/21674030
http://dx.doi.org/10.1371/journal.pone.0020393

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