Phenylbutyrate Counteracts Shigella Mediated Downregulation of Cathelicidin in Rabbit Lung and Intestinal Epithelia: A Potential Therapeutic Strategy

BACKGROUND: Cathelicidins and defensins are endogenous antimicrobial peptides (AMPs) that are downregulated in the mucosal epithelia of the large intestine in shigellosis. Oral treatment of Shigella infected rabbits with sodium butyrate (NaB) reduces clinical severity and counteracts the downregulat...

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Detalles Bibliográficos
Autores principales: Sarker, Protim, Ahmed, Sultan, Tiash, Snigdha, Rekha, Rokeya Sultana, Stromberg, Roger, Andersson, Jan, Bergman, Peter, Gudmundsson, Gudmundur H., Agerberth, Birgitta, Raqib, Rubhana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3108617/
https://www.ncbi.nlm.nih.gov/pubmed/21673991
http://dx.doi.org/10.1371/journal.pone.0020637

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3108617/
https://www.ncbi.nlm.nih.gov/pubmed/21673991
http://dx.doi.org/10.1371/journal.pone.0020637

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