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Management of refractory Pseudomonas aeruginosa infection in cystic fibrosis
Cystic fibrosis (CF) is the most common life-limiting inherited disease in Caucasian populations. The main cause of death in CF patients is respiratory failure resulting from chronic pulmonary infection. Pseudomonas aeruginosa is the most prevalent organism in the airway colonization of CF patients,...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3108754/ https://www.ncbi.nlm.nih.gov/pubmed/21694907 http://dx.doi.org/10.2147/IDR.S16263 |
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author | Sordé, Roger Pahissa, Albert Rello, Jordi |
author_facet | Sordé, Roger Pahissa, Albert Rello, Jordi |
author_sort | Sordé, Roger |
collection | PubMed |
description | Cystic fibrosis (CF) is the most common life-limiting inherited disease in Caucasian populations. The main cause of death in CF patients is respiratory failure resulting from chronic pulmonary infection. Pseudomonas aeruginosa is the most prevalent organism in the airway colonization of CF patients, and its persistence in the airways has been related to greater morbidity with a more rapid deterioration in lung function. P. aeruginosa has enormous genetic and metabolic flexibility that allows it to adapt and persist within the airways of CF patients, and it has the ability to easily acquire antimicrobial resistance. For these reasons, the management of infections and chronic colonization by P. aeruginosa remains a challenge for physicians. This article reviews the current and future antibacterial chemotherapy options for respiratory pseudomonal infection in CF patients. |
format | Online Article Text |
id | pubmed-3108754 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-31087542011-06-21 Management of refractory Pseudomonas aeruginosa infection in cystic fibrosis Sordé, Roger Pahissa, Albert Rello, Jordi Infect Drug Resist Review Cystic fibrosis (CF) is the most common life-limiting inherited disease in Caucasian populations. The main cause of death in CF patients is respiratory failure resulting from chronic pulmonary infection. Pseudomonas aeruginosa is the most prevalent organism in the airway colonization of CF patients, and its persistence in the airways has been related to greater morbidity with a more rapid deterioration in lung function. P. aeruginosa has enormous genetic and metabolic flexibility that allows it to adapt and persist within the airways of CF patients, and it has the ability to easily acquire antimicrobial resistance. For these reasons, the management of infections and chronic colonization by P. aeruginosa remains a challenge for physicians. This article reviews the current and future antibacterial chemotherapy options for respiratory pseudomonal infection in CF patients. Dove Medical Press 2011-01-25 /pmc/articles/PMC3108754/ /pubmed/21694907 http://dx.doi.org/10.2147/IDR.S16263 Text en © 2011 Sordé et al, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited. |
spellingShingle | Review Sordé, Roger Pahissa, Albert Rello, Jordi Management of refractory Pseudomonas aeruginosa infection in cystic fibrosis |
title | Management of refractory Pseudomonas aeruginosa infection in cystic fibrosis |
title_full | Management of refractory Pseudomonas aeruginosa infection in cystic fibrosis |
title_fullStr | Management of refractory Pseudomonas aeruginosa infection in cystic fibrosis |
title_full_unstemmed | Management of refractory Pseudomonas aeruginosa infection in cystic fibrosis |
title_short | Management of refractory Pseudomonas aeruginosa infection in cystic fibrosis |
title_sort | management of refractory pseudomonas aeruginosa infection in cystic fibrosis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3108754/ https://www.ncbi.nlm.nih.gov/pubmed/21694907 http://dx.doi.org/10.2147/IDR.S16263 |
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