The Role of Calcineurin/NFAT in SFRP2 Induced Angiogenesis—A Rationale for Breast Cancer Treatment with the Calcineurin Inhibitor Tacrolimus

Tacrolimus (FK506) is an immunosuppressive drug that binds to the immunophilin FKBPB12. The FK506-FKBP12 complex associates with calcineurin and inhibits its phosphatase activity, resulting in inhibition of nuclear translocation of nuclear factor of activated T-cells (NFAT). There is increasing data...

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Detalles Bibliográficos
Autores principales: Siamakpour-Reihani, Sharareh, Caster, Joseph, Bandhu Nepal, Desh, Courtwright, Andrew, Hilliard, Eleanor, Usary, Jerry, Ketelsen, David, Darr, David, Shen, Xiang Jun, Patterson, Cam, Klauber-DeMore, Nancy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3108822/
https://www.ncbi.nlm.nih.gov/pubmed/21673995
http://dx.doi.org/10.1371/journal.pone.0020412

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