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Proteomic Evaluation and Validation of Cathepsin D Regulated Proteins in Macrophages Exposed to Streptococcus pneumoniae

Macrophages are central effectors of innate immune responses to bacteria. We have investigated how activation of the abundant macrophage lysosomal protease, cathepsin D, regulates the macrophage proteome during killing of Streptococcus pneumoniae. Using the cathepsin D inhibitor pepstatin A, we demo...

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Detalles Bibliográficos
Autores principales:	Bewley, Martin A., Pham, Trong K., Marriott, Helen M., Noirel, Josselin, Chu, Hseuh-Ping, Ow, Saw Y., Ryazanov, Alexey G., Read, Robert C., Whyte, Moira K. B., Chain, Benny, Wright, Phillip C., Dockrell, David H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Biochemistry and Molecular Biology 2011
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3108842/ https://www.ncbi.nlm.nih.gov/pubmed/21474794 http://dx.doi.org/10.1074/mcp.M111.008193

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