Characterising the RNA targets and position-dependent splicing regulation by TDP-43; implications for neurodegenerative diseases

TDP-43 is a predominantly nuclear RNA-binding protein that forms inclusion bodies in frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). The mRNA targets of TDP-43 in the human brain and its role in RNA processing are largely unknown. Using individual-nucleotide resolut...

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Detalles Bibliográficos
Autores principales: Tollervey, James R., Curk, Tomaž, Rogelj, Boris, Briese, Michael, Cereda, Matteo, Kayikci, Melis, Hortobágyi, Tibor, Nishimura, Agnes L., Župunski, Vera, Patani, Rickie, Chandran, Siddharthan, Rot, Gregor, Zupan, Blaž, Shaw, Christopher E., Ule, Jernej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3108889/
https://www.ncbi.nlm.nih.gov/pubmed/21358640
http://dx.doi.org/10.1038/nn.2778

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