Retinoic Acid-Treated Pluripotent Stem Cells Undergoing Neurogenesis Present Increased Aneuploidy and Micronuclei Formation

The existence of loss and gain of chromosomes, known as aneuploidy, has been previously described within the central nervous system. During development, at least one-third of neural progenitor cells (NPCs) are aneuploid. Notably, aneuploid NPCs may survive and functionally integrate into the mature...

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Detalles Bibliográficos
Autores principales: Sartore, Rafaela C., Campos, Priscila B., Trujillo, Cleber A., Ramalho, Bia L., Negraes, Priscilla D., Paulsen, Bruna S., Meletti, Tamara, Costa, Elaine S., Chicaybam, Leonardo, Bonamino, Martin H., Ulrich, Henning, Rehen, Stevens K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3108948/
https://www.ncbi.nlm.nih.gov/pubmed/21674001
http://dx.doi.org/10.1371/journal.pone.0020667

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