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Genome-Wide Association Study of Schizophrenia in Japanese Population

Schizophrenia is a devastating neuropsychiatric disorder with genetically complex traits. Genetic variants should explain a considerable portion of the risk for schizophrenia, and genome-wide association study (GWAS) is a potentially powerful tool for identifying the risk variants that underlie the...

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Autores principales: Yamada, Kazuo, Iwayama, Yoshimi, Hattori, Eiji, Iwamoto, Kazuya, Toyota, Tomoko, Ohnishi, Tetsuo, Ohba, Hisako, Maekawa, Motoko, Kato, Tadafumi, Yoshikawa, Takeo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3108953/
https://www.ncbi.nlm.nih.gov/pubmed/21674006
http://dx.doi.org/10.1371/journal.pone.0020468
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author Yamada, Kazuo
Iwayama, Yoshimi
Hattori, Eiji
Iwamoto, Kazuya
Toyota, Tomoko
Ohnishi, Tetsuo
Ohba, Hisako
Maekawa, Motoko
Kato, Tadafumi
Yoshikawa, Takeo
author_facet Yamada, Kazuo
Iwayama, Yoshimi
Hattori, Eiji
Iwamoto, Kazuya
Toyota, Tomoko
Ohnishi, Tetsuo
Ohba, Hisako
Maekawa, Motoko
Kato, Tadafumi
Yoshikawa, Takeo
author_sort Yamada, Kazuo
collection PubMed
description Schizophrenia is a devastating neuropsychiatric disorder with genetically complex traits. Genetic variants should explain a considerable portion of the risk for schizophrenia, and genome-wide association study (GWAS) is a potentially powerful tool for identifying the risk variants that underlie the disease. Here, we report the results of a three-stage analysis of three independent cohorts consisting of a total of 2,535 samples from Japanese and Chinese populations for searching schizophrenia susceptibility genes using a GWAS approach. Firstly, we examined 115,770 single nucleotide polymorphisms (SNPs) in 120 patient-parents trio samples from Japanese schizophrenia pedigrees. In stage II, we evaluated 1,632 SNPs (1,159 SNPs of p<0.01 and 473 SNPs of p<0.05 that located in previously reported linkage regions). The second sample consisted of 1,012 case-control samples of Japanese origin. The most significant p value was obtained for the SNP in the ELAVL2 [(embryonic lethal, abnormal vision, Drosophila)-like 2] gene located on 9p21.3 (p = 0.00087). In stage III, we scrutinized the ELAVL2 gene by genotyping gene-centric tagSNPs in the third sample set of 293 family samples (1,163 individuals) of Chinese descent and the SNP in the gene showed a nominal association with schizophrenia in Chinese population (p = 0.026). The current data in Asian population would be helpful for deciphering ethnic diversity of schizophrenia etiology.
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spelling pubmed-31089532011-06-13 Genome-Wide Association Study of Schizophrenia in Japanese Population Yamada, Kazuo Iwayama, Yoshimi Hattori, Eiji Iwamoto, Kazuya Toyota, Tomoko Ohnishi, Tetsuo Ohba, Hisako Maekawa, Motoko Kato, Tadafumi Yoshikawa, Takeo PLoS One Research Article Schizophrenia is a devastating neuropsychiatric disorder with genetically complex traits. Genetic variants should explain a considerable portion of the risk for schizophrenia, and genome-wide association study (GWAS) is a potentially powerful tool for identifying the risk variants that underlie the disease. Here, we report the results of a three-stage analysis of three independent cohorts consisting of a total of 2,535 samples from Japanese and Chinese populations for searching schizophrenia susceptibility genes using a GWAS approach. Firstly, we examined 115,770 single nucleotide polymorphisms (SNPs) in 120 patient-parents trio samples from Japanese schizophrenia pedigrees. In stage II, we evaluated 1,632 SNPs (1,159 SNPs of p<0.01 and 473 SNPs of p<0.05 that located in previously reported linkage regions). The second sample consisted of 1,012 case-control samples of Japanese origin. The most significant p value was obtained for the SNP in the ELAVL2 [(embryonic lethal, abnormal vision, Drosophila)-like 2] gene located on 9p21.3 (p = 0.00087). In stage III, we scrutinized the ELAVL2 gene by genotyping gene-centric tagSNPs in the third sample set of 293 family samples (1,163 individuals) of Chinese descent and the SNP in the gene showed a nominal association with schizophrenia in Chinese population (p = 0.026). The current data in Asian population would be helpful for deciphering ethnic diversity of schizophrenia etiology. Public Library of Science 2011-06-06 /pmc/articles/PMC3108953/ /pubmed/21674006 http://dx.doi.org/10.1371/journal.pone.0020468 Text en Yamada et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Yamada, Kazuo
Iwayama, Yoshimi
Hattori, Eiji
Iwamoto, Kazuya
Toyota, Tomoko
Ohnishi, Tetsuo
Ohba, Hisako
Maekawa, Motoko
Kato, Tadafumi
Yoshikawa, Takeo
Genome-Wide Association Study of Schizophrenia in Japanese Population
title Genome-Wide Association Study of Schizophrenia in Japanese Population
title_full Genome-Wide Association Study of Schizophrenia in Japanese Population
title_fullStr Genome-Wide Association Study of Schizophrenia in Japanese Population
title_full_unstemmed Genome-Wide Association Study of Schizophrenia in Japanese Population
title_short Genome-Wide Association Study of Schizophrenia in Japanese Population
title_sort genome-wide association study of schizophrenia in japanese population
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3108953/
https://www.ncbi.nlm.nih.gov/pubmed/21674006
http://dx.doi.org/10.1371/journal.pone.0020468
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