RyRCa(2+) Leak Limits Cardiac Ca(2+) Window Current Overcoming the Tonic Effect of Calmodulin in Mice

Ca(2+) mediates the functional coupling between L-type Ca(2+) channel (LTCC) and sarcoplasmic reticulum (SR) Ca(2+) release channel (ryanodine receptor, RyR), participating in key pathophysiological processes. This crosstalk manifests as the orthograde Ca(2+)-induced Ca(2+)-release (CICR) mechanism...

Descripción completa

Detalles Bibliográficos
Autores principales: Fernández-Velasco, María, Ruiz-Hurtado, Gema, Rueda, Angélica, Neco, Patricia, Mercado-Morales, Martha, Delgado, Carmen, Napolitano, Carlo, Priori, Silvia G., Richard, Sylvain, María Gómez, Ana, Benitah, Jean-Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3108979/
https://www.ncbi.nlm.nih.gov/pubmed/21673970
http://dx.doi.org/10.1371/journal.pone.0020863

Ejemplares similares

Ejemplares similares