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Expression of Sumoylation Deficient Nkx2.5 Mutant in Nkx2.5 Haploinsufficient Mice Leads to Congenital Heart Defects

Nkx2.5 is a cardiac specific homeobox gene critical for normal heart development. We previously identified Nkx2.5 as a target of sumoylation, a posttranslational modification implicated in a variety of cellular activities. Sumoylation enhanced Nkx2.5 activity via covalent attachment to the lysine re...

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Detalles Bibliográficos
Autores principales:	Kim, Eun Young, Chen, Li, Ma, Yanlin, Yu, Wei, Chang, Jiang, Moskowitz, Ivan P., Wang, Jun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3108998/ https://www.ncbi.nlm.nih.gov/pubmed/21677783 http://dx.doi.org/10.1371/journal.pone.0020803

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