IC261 induces cell cycle arrest and apoptosis of human cancer cells via CK1δ/ɛ and Wnt/β-catenin independent inhibition of mitotic spindle formation

Casein kinase 1 delta and epsilon (CK1δ/ɛ) are key regulators of diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. Recent studies suggest that they have an important role in oncogenesis. RNA interference screens identified CK1ɛ as a pro-surviva...

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Detalles Bibliográficos
Autores principales: Cheong, J K, Hung, N T, Wang, H, Tan, P, Voorhoeve, P M, Lee, S H, Virshup, D M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2011
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3109269/
https://www.ncbi.nlm.nih.gov/pubmed/21258417
http://dx.doi.org/10.1038/onc.2010.627

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