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Therapeutic Effects of Hydrogen in Animal Models of Parkinson's Disease
Since the first description of Parkinson's disease (PD) nearly two centuries ago, a number of studies have revealed the clinical symptoms, pathology, and therapeutic approaches to overcome this intractable neurodegenerative disease. 1-methy-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 6-hydro...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE-Hindawi Access to Research
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3109337/ https://www.ncbi.nlm.nih.gov/pubmed/21687749 http://dx.doi.org/10.4061/2011/307875 |
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author | Fujita, Kyota Nakabeppu, Yusaku Noda, Mami |
author_facet | Fujita, Kyota Nakabeppu, Yusaku Noda, Mami |
author_sort | Fujita, Kyota |
collection | PubMed |
description | Since the first description of Parkinson's disease (PD) nearly two centuries ago, a number of studies have revealed the clinical symptoms, pathology, and therapeutic approaches to overcome this intractable neurodegenerative disease. 1-methy-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 6-hydroxydopamine (6-OHDA) are neurotoxins which produce Parkinsonian pathology. From the animal studies using these neurotoxins, it has become well established that oxidative stress is a primary cause of, and essential for, cellular apoptosis in dopaminergic neurons. Here, we describe the mechanism whereby oxidative stress evokes irreversible cell death, and propose a novel therapeutic strategy for PD using molecular hydrogen. Hydrogen has an ability to reduce oxidative damage and ameliorate the loss of nigrostriatal dopaminergic neuronal pathway in two experimental animal models. Thus, it is strongly suggested that hydrogen might provide a great advantage to prevent or minimize the onset and progression of PD. |
format | Online Article Text |
id | pubmed-3109337 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | SAGE-Hindawi Access to Research |
record_format | MEDLINE/PubMed |
spelling | pubmed-31093372011-06-17 Therapeutic Effects of Hydrogen in Animal Models of Parkinson's Disease Fujita, Kyota Nakabeppu, Yusaku Noda, Mami Parkinsons Dis Review Article Since the first description of Parkinson's disease (PD) nearly two centuries ago, a number of studies have revealed the clinical symptoms, pathology, and therapeutic approaches to overcome this intractable neurodegenerative disease. 1-methy-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 6-hydroxydopamine (6-OHDA) are neurotoxins which produce Parkinsonian pathology. From the animal studies using these neurotoxins, it has become well established that oxidative stress is a primary cause of, and essential for, cellular apoptosis in dopaminergic neurons. Here, we describe the mechanism whereby oxidative stress evokes irreversible cell death, and propose a novel therapeutic strategy for PD using molecular hydrogen. Hydrogen has an ability to reduce oxidative damage and ameliorate the loss of nigrostriatal dopaminergic neuronal pathway in two experimental animal models. Thus, it is strongly suggested that hydrogen might provide a great advantage to prevent or minimize the onset and progression of PD. SAGE-Hindawi Access to Research 2011-04-26 /pmc/articles/PMC3109337/ /pubmed/21687749 http://dx.doi.org/10.4061/2011/307875 Text en Copyright © 2011 Kyota Fujita et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Fujita, Kyota Nakabeppu, Yusaku Noda, Mami Therapeutic Effects of Hydrogen in Animal Models of Parkinson's Disease |
title | Therapeutic Effects of Hydrogen in Animal Models of Parkinson's Disease |
title_full | Therapeutic Effects of Hydrogen in Animal Models of Parkinson's Disease |
title_fullStr | Therapeutic Effects of Hydrogen in Animal Models of Parkinson's Disease |
title_full_unstemmed | Therapeutic Effects of Hydrogen in Animal Models of Parkinson's Disease |
title_short | Therapeutic Effects of Hydrogen in Animal Models of Parkinson's Disease |
title_sort | therapeutic effects of hydrogen in animal models of parkinson's disease |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3109337/ https://www.ncbi.nlm.nih.gov/pubmed/21687749 http://dx.doi.org/10.4061/2011/307875 |
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