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Therapeutic Effects of Hydrogen in Animal Models of Parkinson's Disease

Since the first description of Parkinson's disease (PD) nearly two centuries ago, a number of studies have revealed the clinical symptoms, pathology, and therapeutic approaches to overcome this intractable neurodegenerative disease. 1-methy-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 6-hydro...

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Autores principales: Fujita, Kyota, Nakabeppu, Yusaku, Noda, Mami
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE-Hindawi Access to Research 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3109337/
https://www.ncbi.nlm.nih.gov/pubmed/21687749
http://dx.doi.org/10.4061/2011/307875
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author Fujita, Kyota
Nakabeppu, Yusaku
Noda, Mami
author_facet Fujita, Kyota
Nakabeppu, Yusaku
Noda, Mami
author_sort Fujita, Kyota
collection PubMed
description Since the first description of Parkinson's disease (PD) nearly two centuries ago, a number of studies have revealed the clinical symptoms, pathology, and therapeutic approaches to overcome this intractable neurodegenerative disease. 1-methy-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 6-hydroxydopamine (6-OHDA) are neurotoxins which produce Parkinsonian pathology. From the animal studies using these neurotoxins, it has become well established that oxidative stress is a primary cause of, and essential for, cellular apoptosis in dopaminergic neurons. Here, we describe the mechanism whereby oxidative stress evokes irreversible cell death, and propose a novel therapeutic strategy for PD using molecular hydrogen. Hydrogen has an ability to reduce oxidative damage and ameliorate the loss of nigrostriatal dopaminergic neuronal pathway in two experimental animal models. Thus, it is strongly suggested that hydrogen might provide a great advantage to prevent or minimize the onset and progression of PD.
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spelling pubmed-31093372011-06-17 Therapeutic Effects of Hydrogen in Animal Models of Parkinson's Disease Fujita, Kyota Nakabeppu, Yusaku Noda, Mami Parkinsons Dis Review Article Since the first description of Parkinson's disease (PD) nearly two centuries ago, a number of studies have revealed the clinical symptoms, pathology, and therapeutic approaches to overcome this intractable neurodegenerative disease. 1-methy-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 6-hydroxydopamine (6-OHDA) are neurotoxins which produce Parkinsonian pathology. From the animal studies using these neurotoxins, it has become well established that oxidative stress is a primary cause of, and essential for, cellular apoptosis in dopaminergic neurons. Here, we describe the mechanism whereby oxidative stress evokes irreversible cell death, and propose a novel therapeutic strategy for PD using molecular hydrogen. Hydrogen has an ability to reduce oxidative damage and ameliorate the loss of nigrostriatal dopaminergic neuronal pathway in two experimental animal models. Thus, it is strongly suggested that hydrogen might provide a great advantage to prevent or minimize the onset and progression of PD. SAGE-Hindawi Access to Research 2011-04-26 /pmc/articles/PMC3109337/ /pubmed/21687749 http://dx.doi.org/10.4061/2011/307875 Text en Copyright © 2011 Kyota Fujita et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Fujita, Kyota
Nakabeppu, Yusaku
Noda, Mami
Therapeutic Effects of Hydrogen in Animal Models of Parkinson's Disease
title Therapeutic Effects of Hydrogen in Animal Models of Parkinson's Disease
title_full Therapeutic Effects of Hydrogen in Animal Models of Parkinson's Disease
title_fullStr Therapeutic Effects of Hydrogen in Animal Models of Parkinson's Disease
title_full_unstemmed Therapeutic Effects of Hydrogen in Animal Models of Parkinson's Disease
title_short Therapeutic Effects of Hydrogen in Animal Models of Parkinson's Disease
title_sort therapeutic effects of hydrogen in animal models of parkinson's disease
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3109337/
https://www.ncbi.nlm.nih.gov/pubmed/21687749
http://dx.doi.org/10.4061/2011/307875
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