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Lifetime psychopathology among the offspring of Bipolar I parents
BACKGROUND: Recent studies have demonstrated high rates of psychopathology in the offspring of parents with bipolar disorder. The aim of this study was to identify psychiatric diagnoses in a sample of children of bipolar parents. METHOD: This case series comprised 35 children and adolescents aged 6...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3109366/ https://www.ncbi.nlm.nih.gov/pubmed/21789371 http://dx.doi.org/10.1590/S1807-59322011000500003 |
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author | Zappitelli, Marcelo C Bordin, Isabel A Hatch, John P Caetano, Sheila C Zunta-Soares, Giovana Olvera, Rene L Soares, Jair C |
author_facet | Zappitelli, Marcelo C Bordin, Isabel A Hatch, John P Caetano, Sheila C Zunta-Soares, Giovana Olvera, Rene L Soares, Jair C |
author_sort | Zappitelli, Marcelo C |
collection | PubMed |
description | BACKGROUND: Recent studies have demonstrated high rates of psychopathology in the offspring of parents with bipolar disorder. The aim of this study was to identify psychiatric diagnoses in a sample of children of bipolar parents. METHOD: This case series comprised 35 children and adolescents aged 6 to 17 years, with a mean age of 12.5±2.9 years (20 males and 15 females), who had at least one parent with bipolar disorder type I. The subjects were assessed using the Schedule for Affective Disorders and Schizophrenia for School-Age Children – Present and Lifetime version (K-SADS-PL). Family psychiatric history and demographics were also evaluated. RESULTS: Of the offspring studied, 71.4% had a lifetime diagnosis of at least one psychiatric disorder (28.6% with a mood disorder, 40% with a disruptive behavior disorder and 20% with an anxiety disorder). Pure mood disorders (11.4%) occurred less frequently than mood disorders comorbid with attention deficit hyperactivity disorder (17.1%). Psychopathology was commonly reported in second-degree relatives of the offspring of parents with bipolar disorder (71.4%). CONCLUSIONS: Our results support previous findings of an increased risk for developing psychopathology, predominantly mood and disruptive disorders, in the offspring of bipolar individuals. Prospective studies with larger samples are needed to confirm and expand these results. |
format | Online Article Text |
id | pubmed-3109366 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo |
record_format | MEDLINE/PubMed |
spelling | pubmed-31093662011-06-07 Lifetime psychopathology among the offspring of Bipolar I parents Zappitelli, Marcelo C Bordin, Isabel A Hatch, John P Caetano, Sheila C Zunta-Soares, Giovana Olvera, Rene L Soares, Jair C Clinics (Sao Paulo) Clinical Science BACKGROUND: Recent studies have demonstrated high rates of psychopathology in the offspring of parents with bipolar disorder. The aim of this study was to identify psychiatric diagnoses in a sample of children of bipolar parents. METHOD: This case series comprised 35 children and adolescents aged 6 to 17 years, with a mean age of 12.5±2.9 years (20 males and 15 females), who had at least one parent with bipolar disorder type I. The subjects were assessed using the Schedule for Affective Disorders and Schizophrenia for School-Age Children – Present and Lifetime version (K-SADS-PL). Family psychiatric history and demographics were also evaluated. RESULTS: Of the offspring studied, 71.4% had a lifetime diagnosis of at least one psychiatric disorder (28.6% with a mood disorder, 40% with a disruptive behavior disorder and 20% with an anxiety disorder). Pure mood disorders (11.4%) occurred less frequently than mood disorders comorbid with attention deficit hyperactivity disorder (17.1%). Psychopathology was commonly reported in second-degree relatives of the offspring of parents with bipolar disorder (71.4%). CONCLUSIONS: Our results support previous findings of an increased risk for developing psychopathology, predominantly mood and disruptive disorders, in the offspring of bipolar individuals. Prospective studies with larger samples are needed to confirm and expand these results. Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo 2011-05 /pmc/articles/PMC3109366/ /pubmed/21789371 http://dx.doi.org/10.1590/S1807-59322011000500003 Text en Copyright © 2011 Hospital das Clínicas da FMUSP http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Science Zappitelli, Marcelo C Bordin, Isabel A Hatch, John P Caetano, Sheila C Zunta-Soares, Giovana Olvera, Rene L Soares, Jair C Lifetime psychopathology among the offspring of Bipolar I parents |
title | Lifetime psychopathology among the offspring of Bipolar I parents |
title_full | Lifetime psychopathology among the offspring of Bipolar I parents |
title_fullStr | Lifetime psychopathology among the offspring of Bipolar I parents |
title_full_unstemmed | Lifetime psychopathology among the offspring of Bipolar I parents |
title_short | Lifetime psychopathology among the offspring of Bipolar I parents |
title_sort | lifetime psychopathology among the offspring of bipolar i parents |
topic | Clinical Science |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3109366/ https://www.ncbi.nlm.nih.gov/pubmed/21789371 http://dx.doi.org/10.1590/S1807-59322011000500003 |
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