The role of oxidative stress and antioxidants in the pathogenesis of age-related macular degeneration

OBJECTIVE: To investigate the role of oxidant/antioxidant status and protein oxidation in the development of age-related macular degeneration. METHOD: The activities of serum superoxide dismutase and glutathione peroxidase and the levels of serum malondialdehyde, advanced oxidation protein products,...

Descripción completa

Detalles Bibliográficos
Autores principales: Yildirim, Zuhal, Ucgun, Nil Irem, Yildirim, Filiz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo 2011
Materias:
Clinical Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3109369/
https://www.ncbi.nlm.nih.gov/pubmed/21789374
http://dx.doi.org/10.1590/S1807-59322011000500006
_version_ 1782205425711579136
author Yildirim, Zuhal
Ucgun, Nil Irem
Yildirim, Filiz
author_facet Yildirim, Zuhal
Ucgun, Nil Irem
Yildirim, Filiz
author_sort Yildirim, Zuhal
collection PubMed
description OBJECTIVE: To investigate the role of oxidant/antioxidant status and protein oxidation in the development of age-related macular degeneration. METHOD: The activities of serum superoxide dismutase and glutathione peroxidase and the levels of serum malondialdehyde, advanced oxidation protein products, glutathione and vitamin C were measured in 25 patients with age-related macular degeneration and 25 control subjects without age-related macular degeneration. RESULT: The malondialdehyde and advanced oxidation protein product levels in the serum were significantly higher in the age-related macular degeneration patient group than in the control group (p<0.05). The superoxide dismutase activity in the serum was significantly lower in the age-related macular degeneration patient group than in the control group (p<0.05). The levels of vitamin C and glutathione and the activity of glutathione peroxidase in the serum were unchanged between groups (p>0.05). CONCLUSION: The results of the present study suggest that decreased effectiveness of the antioxidant defense system and increased oxidative stress may play a role in the pathogenesis of age-related macular degeneration.
format Online
Article
Text
id pubmed-3109369
institution National Center for Biotechnology Information
language English
publishDate 2011
publisher Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
record_format MEDLINE/PubMed
spelling pubmed-31093692011-06-07 The role of oxidative stress and antioxidants in the pathogenesis of age-related macular degeneration Yildirim, Zuhal Ucgun, Nil Irem Yildirim, Filiz Clinics (Sao Paulo) Clinical Science OBJECTIVE: To investigate the role of oxidant/antioxidant status and protein oxidation in the development of age-related macular degeneration. METHOD: The activities of serum superoxide dismutase and glutathione peroxidase and the levels of serum malondialdehyde, advanced oxidation protein products, glutathione and vitamin C were measured in 25 patients with age-related macular degeneration and 25 control subjects without age-related macular degeneration. RESULT: The malondialdehyde and advanced oxidation protein product levels in the serum were significantly higher in the age-related macular degeneration patient group than in the control group (p<0.05). The superoxide dismutase activity in the serum was significantly lower in the age-related macular degeneration patient group than in the control group (p<0.05). The levels of vitamin C and glutathione and the activity of glutathione peroxidase in the serum were unchanged between groups (p>0.05). CONCLUSION: The results of the present study suggest that decreased effectiveness of the antioxidant defense system and increased oxidative stress may play a role in the pathogenesis of age-related macular degeneration. Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo 2011-05 /pmc/articles/PMC3109369/ /pubmed/21789374 http://dx.doi.org/10.1590/S1807-59322011000500006 Text en Copyright © 2011 Hospital das Clínicas da FMUSP http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Science
Yildirim, Zuhal
Ucgun, Nil Irem
Yildirim, Filiz
The role of oxidative stress and antioxidants in the pathogenesis of age-related macular degeneration
title The role of oxidative stress and antioxidants in the pathogenesis of age-related macular degeneration
title_full The role of oxidative stress and antioxidants in the pathogenesis of age-related macular degeneration
title_fullStr The role of oxidative stress and antioxidants in the pathogenesis of age-related macular degeneration
title_full_unstemmed The role of oxidative stress and antioxidants in the pathogenesis of age-related macular degeneration
title_short The role of oxidative stress and antioxidants in the pathogenesis of age-related macular degeneration
title_sort role of oxidative stress and antioxidants in the pathogenesis of age-related macular degeneration
topic Clinical Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3109369/
https://www.ncbi.nlm.nih.gov/pubmed/21789374
http://dx.doi.org/10.1590/S1807-59322011000500006
work_keys_str_mv AT yildirimzuhal theroleofoxidativestressandantioxidantsinthepathogenesisofagerelatedmaculardegeneration
AT ucgunnilirem theroleofoxidativestressandantioxidantsinthepathogenesisofagerelatedmaculardegeneration
AT yildirimfiliz theroleofoxidativestressandantioxidantsinthepathogenesisofagerelatedmaculardegeneration
AT yildirimzuhal roleofoxidativestressandantioxidantsinthepathogenesisofagerelatedmaculardegeneration
AT ucgunnilirem roleofoxidativestressandantioxidantsinthepathogenesisofagerelatedmaculardegeneration
AT yildirimfiliz roleofoxidativestressandantioxidantsinthepathogenesisofagerelatedmaculardegeneration

Ejemplares similares