Non-linear relationships of cerebrospinal fluid biomarker levels with cognitive function: an observational study

INTRODUCTION: Levels of cerebrospinal fluid (CSF) β-amyloid (Aβ) and Tau proteins change in Alzheimer's disease (AD). We tested if the relationships of these biomarkers with cognitive impairment are linear or non-linear. METHODS: We assessed cognitive function and assayed CSF Aβ and Tau biomark...

Descripción completa

Detalles Bibliográficos
Autores principales: Williams, Jonathan H, Wilcock, Gordon K, Seeburger, Jeffrey, Dallob, Aimee, Laterza, Omar, Potter, William, Smith, A David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3109414/
https://www.ncbi.nlm.nih.gov/pubmed/21329517
http://dx.doi.org/10.1186/alzrt64
_version_ 1782205435662565376
author Williams, Jonathan H
Wilcock, Gordon K
Seeburger, Jeffrey
Dallob, Aimee
Laterza, Omar
Potter, William
Smith, A David
author_facet Williams, Jonathan H
Wilcock, Gordon K
Seeburger, Jeffrey
Dallob, Aimee
Laterza, Omar
Potter, William
Smith, A David
author_sort Williams, Jonathan H
collection PubMed
description INTRODUCTION: Levels of cerebrospinal fluid (CSF) β-amyloid (Aβ) and Tau proteins change in Alzheimer's disease (AD). We tested if the relationships of these biomarkers with cognitive impairment are linear or non-linear. METHODS: We assessed cognitive function and assayed CSF Aβ and Tau biomarkers in 95 non-demented volunteers and 97 AD patients. We then tested non-linearities in their inter-relations. RESULTS: CSF biomarkers related to cognitive function in the non-demented range of cognition, but these relations were weak or absent in the patient range; Aβ(1-40)'s relationship was biphasic. CONCLUSIONS: Major biomarker changes precede clinical AD and index cognitive impairment in AD poorly, if at all.
format Online
Article
Text
id pubmed-3109414
institution National Center for Biotechnology Information
language English
publishDate 2011
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-31094142011-06-08 Non-linear relationships of cerebrospinal fluid biomarker levels with cognitive function: an observational study Williams, Jonathan H Wilcock, Gordon K Seeburger, Jeffrey Dallob, Aimee Laterza, Omar Potter, William Smith, A David Alzheimers Res Ther Research INTRODUCTION: Levels of cerebrospinal fluid (CSF) β-amyloid (Aβ) and Tau proteins change in Alzheimer's disease (AD). We tested if the relationships of these biomarkers with cognitive impairment are linear or non-linear. METHODS: We assessed cognitive function and assayed CSF Aβ and Tau biomarkers in 95 non-demented volunteers and 97 AD patients. We then tested non-linearities in their inter-relations. RESULTS: CSF biomarkers related to cognitive function in the non-demented range of cognition, but these relations were weak or absent in the patient range; Aβ(1-40)'s relationship was biphasic. CONCLUSIONS: Major biomarker changes precede clinical AD and index cognitive impairment in AD poorly, if at all. BioMed Central 2011-02-17 /pmc/articles/PMC3109414/ /pubmed/21329517 http://dx.doi.org/10.1186/alzrt64 Text en Copyright ©2011 Williams et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Williams, Jonathan H
Wilcock, Gordon K
Seeburger, Jeffrey
Dallob, Aimee
Laterza, Omar
Potter, William
Smith, A David
Non-linear relationships of cerebrospinal fluid biomarker levels with cognitive function: an observational study
title Non-linear relationships of cerebrospinal fluid biomarker levels with cognitive function: an observational study
title_full Non-linear relationships of cerebrospinal fluid biomarker levels with cognitive function: an observational study
title_fullStr Non-linear relationships of cerebrospinal fluid biomarker levels with cognitive function: an observational study
title_full_unstemmed Non-linear relationships of cerebrospinal fluid biomarker levels with cognitive function: an observational study
title_short Non-linear relationships of cerebrospinal fluid biomarker levels with cognitive function: an observational study
title_sort non-linear relationships of cerebrospinal fluid biomarker levels with cognitive function: an observational study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3109414/
https://www.ncbi.nlm.nih.gov/pubmed/21329517
http://dx.doi.org/10.1186/alzrt64
work_keys_str_mv AT williamsjonathanh nonlinearrelationshipsofcerebrospinalfluidbiomarkerlevelswithcognitivefunctionanobservationalstudy
AT wilcockgordonk nonlinearrelationshipsofcerebrospinalfluidbiomarkerlevelswithcognitivefunctionanobservationalstudy
AT seeburgerjeffrey nonlinearrelationshipsofcerebrospinalfluidbiomarkerlevelswithcognitivefunctionanobservationalstudy
AT dallobaimee nonlinearrelationshipsofcerebrospinalfluidbiomarkerlevelswithcognitivefunctionanobservationalstudy
AT laterzaomar nonlinearrelationshipsofcerebrospinalfluidbiomarkerlevelswithcognitivefunctionanobservationalstudy
AT potterwilliam nonlinearrelationshipsofcerebrospinalfluidbiomarkerlevelswithcognitivefunctionanobservationalstudy
AT smithadavid nonlinearrelationshipsofcerebrospinalfluidbiomarkerlevelswithcognitivefunctionanobservationalstudy

Ejemplares similares