A local basis for progesterone action during mammary tumorigenesis - no longer RANK and file

Two recent reports provide compelling insights into the role for RANK and its ligand, RANKL, in progestin-dependent mammary tumorigenesis. These findings build upon a considerable body of evidence pointing to the RANK signaling pathway as being a key mediator of progestin action in the mammary gland...

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Detalles Bibliográficos
Autores principales: Petrie, Whitney K, Hovey, Russell C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Viewpoint
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3109564/
https://www.ncbi.nlm.nih.gov/pubmed/21345282
http://dx.doi.org/10.1186/bcr2802
Descripción
Sumario:Two recent reports provide compelling insights into the role for RANK and its ligand, RANKL, in progestin-dependent mammary tumorigenesis. These findings build upon a considerable body of evidence pointing to the RANK signaling pathway as being a key mediator of progestin action in the mammary glands.

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