Cargando…

α-Tocopheryloxyacetic acid: a novel chemotherapeutic that stimulates the antitumor immune response

INTRODUCTION: α-Tocopheryloxyacetic acid (α-TEA) is a novel ether derivative of α-tocopherol that has generated interest as a chemotherapeutic agent because of its selective toxicity toward tumor cells and its ability to suppress tumor growth in various rodent and human xenograft models. We previous...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hahn, Tobias, Jagadish, Bhumasamudram, Mash, Eugene A, Garrison, Kendra, Akporiaye, Emmanuel T
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3109570/ https://www.ncbi.nlm.nih.gov/pubmed/21232138 http://dx.doi.org/10.1186/bcr2808

Ejemplares similares

The vitamin E analog, alpha-tocopheryloxyacetic acid enhances the anti-tumor activity of trastuzumab against HER2/neu-expressing breast cancer
por: Hahn, Tobias, et al.
Publicado: (2011)

Magnetic Resonance Imaging Identifies Differential Response to Pro-Oxidant Chemotherapy in a Xenograft Model()
por: Landowski, Terry H., et al.
Publicado: (2016)

Magnetic resonance imaging of RRx-001 pharmacodynamics in preclinical tumors
por: Raghunand, Natarajan, et al.
Publicado: (2017)

STAT3 signaling is required for anti-OX40/TGF-β receptor blockade-mediated regression of large established tumors
por: Akporiaye, Emmanuel T, et al.
Publicado: (2013)

GMP-grade α-TEA lysine salt: a 28-Day oral toxicity and toxicokinetic study with a 28-Day recovery period in Beagle dogs
por: Guerrouahen, Bella S., et al.
Publicado: (2016)

pTyr(421) Cortactin Is Overexpressed in Colon Cancer and Is Dephosphorylated by Curcumin: Involvement of Non-Receptor Type 1 Protein Tyrosine Phosphatase (PTPN1)
por: Radhakrishnan, Vijayababu M., et al.
Publicado: (2014)

Antitumor activity of orally administered maitake α-glucan by stimulating antitumor immune response in murine tumor
por: Masuda, Yuki, et al.
Publicado: (2017)

Targeting transforming growth factor β to enhance cancer immunotherapy
por: Hahn, T., et al.
Publicado: (2006)

Blockade of TGF-β signaling to enhance the antitumor response is accompanied by dysregulation of the functional activity of CD4(+)CD25(+)Foxp3(+) and CD4(+)CD25(−)Foxp3(+) T cells
por: Polanczyk, Magdalena J., et al.
Publicado: (2019)

Antitumor Effect of PSK at a Distant Site: Tumor‐specific Immunity and Combination with Other Chemotherapeutic Agents
por: Ebina, Takusaburo, et al.
Publicado: (1992)

Enhancement of anti-tumor efficacy of immune checkpoint blockade by alpha-TEA
por: Redmond, William L., et al.
Publicado: (2023)

Reverting Immune Suppression to Enhance Cancer Immunotherapy
por: Guerrouahen, Bella S., et al.
Publicado: (2020)

Retinoic acid on stage in antitumor immunity
por: Guo, Yanxia, et al.
Publicado: (2013)

Potentiating antitumor immunity with αGC-loaded exosomes
por: Gehrmann, Ulf, et al.
Publicado: (2013)

Combined PD-1 blockade and GITR triggering induce a potent antitumor immunity in murine cancer models and synergizes with chemotherapeutic drugs
por: Lu, Lei, et al.
Publicado: (2014)

Chemotherapeutic potentials of the stem bark of Balanite aegyptiaca (L.) Delile: an antiangiogenic, antitumor and antioxidant agent
por: Hassan, Loiy E. Ahmed, et al.
Publicado: (2016)

Zinc protoporphyrin IX, a heme oxygenase-1 inhibitor, demonstrates potent antitumor effects but is unable to potentiate antitumor effects of chemotherapeutics in mice
por: Nowis, Dominika, et al.
Publicado: (2008)

STATing the importance of immune modulation by platinum chemotherapeutics
por: Hato, Stanleyson V., et al.
Publicado: (2012)

Synergistic antitumor activity of oncolytic reovirus and chemotherapeutic agents in non-small cell lung cancer cells
por: Sei, Shizuko, et al.
Publicado: (2009)

Antitumor Activity of HM781-36B, alone or in Combination with Chemotherapeutic Agents, in Colorectal Cancer Cells
por: Kang, Mi Hyun, et al.
Publicado: (2016)

Tumor Microenvironmental Responsive Liposomes Simultaneously Encapsulating Biological and Chemotherapeutic Drugs for Enhancing Antitumor Efficacy of NSCLC
por: Kong, Liang, et al.
Publicado: (2020)

The Application of Nanotechnology in the Codelivery of Active Constituents of Plants and Chemotherapeutics for Overcoming Physiological Barriers during Antitumor Treatment
por: Li, Qiushuang, et al.
Publicado: (2019)

Chemotherapeutic and targeted drugs-induced immunogenic cell death in cancer models and antitumor therapy: An update review
por: Zhai, Jiaqi, et al.
Publicado: (2023)

Phase I study of alpha-tocopherlyoxyacetic acid in patients with advanced cancer
por: Curti, Brendan D, et al.
Publicado: (2015)

Novel Immune Stimulant Amplifies Direct Tumoricidal Effect of Cancer Ablation Therapies and Their Systemic Antitumor Immune Efficacy
por: Korbelik, Mladen, et al.
Publicado: (2021)

SIRPα blockade improves the antitumor immunity of radiotherapy in colorectal cancer
por: Ji, Kai, et al.
Publicado: (2023)

Tubeimoside 1 Acts as a Chemotherapeutic Synergist via Stimulating Macropinocytosis
por: Gong, Xianling, et al.
Publicado: (2018)

Dichloroacetate enhances the antitumor efficacy of chemotherapeutic agents via inhibiting autophagy in non-small-cell lung cancer
por: Lu, Xiao, et al.
Publicado: (2018)

Anti-claudin-4 extracellular domain antibody enhances the antitumoral effects of chemotherapeutic and antibody drugs in colorectal cancer
por: Fujiwara-Tani, Rina, et al.
Publicado: (2018)

Tumor Microenvironmental Responsive Liposomes Simultaneously Encapsulating Biological and Chemotherapeutic Drugs for Enhancing Antitumor Efficacy of NSCLC [Corrigendum]
Publicado: (2021)

The effects of chemotherapeutics on cellular metabolism and consequent immune recognition
por: Newell, M Karen, et al.
Publicado: (2004)

Chemotherapeutic targeting of myeloid-derived suppressor cells
por: Alizadeh, Darya, et al.
Publicado: (2014)

Antitumor and Adjuvant Activity of λ-carrageenan by Stimulating Immune Response in Cancer Immunotherapy
por: Luo, Min, et al.
Publicado: (2015)

Novel Cancer Immunotherapies and Antitumor Immunity
por: Zhao, Lei, et al.
Publicado: (2019)

Context-Specific and Immune Cell-Dependent Antitumor Activities of α1-Antitrypsin
por: Guttman, Ofer, et al.
Publicado: (2016)

CHEMOTHERAPEUTIC EQUILIBRIA
por: Stearn, Allen E., et al.
Publicado: (1930)

Chemotherapeutic Antiseptics
por: Browning, C. H.
Publicado: (1937)

Insulin enhancement of the antitumor activity of chemotherapeutic agents in colorectal cancer is linked with downregulating PIK3CA and GRB2
por: Agrawal, Siddarth, et al.
Publicado: (2019)

Corrigendum: Tubeimoside 1 Acts as a Chemotherapeutic Synergist via Stimulating Macropinocytosis
por: Gong, Xianling, et al.
Publicado: (2021)

Antitumor Activity of α-Linolenic Acid-Paclitaxel Conjugate Nanoparticles: In vitro and in vivo
por: Xu, Mei-Qi, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_q9budjhq8t38j8cplp1lluvt16