Genetic variation of ESR1 and its co-activator PPARGC1B is synergistic in augmenting the risk of estrogen receptor-positive breast cancer

INTRODUCTION: Given the role of estrogen in breast carcinogenesis and the modification of estrogen receptor (ER) activity by its biochemical cofactors, we hypothesize that genetic variation within ER cofactor genes alters cellular response to estrogen exposure and consequently modifies the risk for...

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Detalles Bibliográficos
Autores principales: Li, Yuqing, Li, Yi, Wedrén, Sara, Li, Guoliang, Charn, Tze Howe, Desai, Kartiki Vasant, Bonnard, Carine, Czene, Kamila, Humphreys, Keith, Darabi, Hatef, Einarsdóttir, Kristjana, Heikkinen, Tuomas, Aittomäki, Kristiina, Blomqvist, Carl, Chia, Kee Seng, Nevanlinna, Heli, Hall, Per, Liu, Edison T, Liu, Jianjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3109578/
https://www.ncbi.nlm.nih.gov/pubmed/21269472
http://dx.doi.org/10.1186/bcr2817

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