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Immune Control of Legionella Infection: An in vivo Perspective
Legionella pneumophila is an intracellular pathogen that replicates within alveolar macrophages. Through its ability to activate multiple host innate immune components, L. pneumophila has emerged as a useful tool to dissect inflammatory signaling pathways in macrophages. However the resolution of L....
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Research Foundation
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3109619/ https://www.ncbi.nlm.nih.gov/pubmed/21687433 http://dx.doi.org/10.3389/fmicb.2011.00126 |
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author | Schuelein, Ralf Ang, Desmond K. Y. van Driel, Ian R. Hartland, Elizabeth L. |
author_facet | Schuelein, Ralf Ang, Desmond K. Y. van Driel, Ian R. Hartland, Elizabeth L. |
author_sort | Schuelein, Ralf |
collection | PubMed |
description | Legionella pneumophila is an intracellular pathogen that replicates within alveolar macrophages. Through its ability to activate multiple host innate immune components, L. pneumophila has emerged as a useful tool to dissect inflammatory signaling pathways in macrophages. However the resolution of L. pneumophila infection in the lung requires multiple cell types and abundant cross talk between immune cells. Few studies have examined the coordination of events that lead to effective immune control of the pathogen. Here we discuss L. pneumophila interactions with macrophages and dendritic cell subsets and highlight the paucity of knowledge around how these interactions recruit and activate other immune effector cells in the lung. |
format | Online Article Text |
id | pubmed-3109619 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Frontiers Research Foundation |
record_format | MEDLINE/PubMed |
spelling | pubmed-31096192011-06-16 Immune Control of Legionella Infection: An in vivo Perspective Schuelein, Ralf Ang, Desmond K. Y. van Driel, Ian R. Hartland, Elizabeth L. Front Microbiol Microbiology Legionella pneumophila is an intracellular pathogen that replicates within alveolar macrophages. Through its ability to activate multiple host innate immune components, L. pneumophila has emerged as a useful tool to dissect inflammatory signaling pathways in macrophages. However the resolution of L. pneumophila infection in the lung requires multiple cell types and abundant cross talk between immune cells. Few studies have examined the coordination of events that lead to effective immune control of the pathogen. Here we discuss L. pneumophila interactions with macrophages and dendritic cell subsets and highlight the paucity of knowledge around how these interactions recruit and activate other immune effector cells in the lung. Frontiers Research Foundation 2011-06-03 /pmc/articles/PMC3109619/ /pubmed/21687433 http://dx.doi.org/10.3389/fmicb.2011.00126 Text en Copyright © 2011 Schuelein, Ang, Driel and Hartland. http://www.frontiersin.org/licenseagreement This is an open-access article subject to a non-exclusive license between the authors and Frontiers Media SA, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and other Frontiers conditions are complied with. |
spellingShingle | Microbiology Schuelein, Ralf Ang, Desmond K. Y. van Driel, Ian R. Hartland, Elizabeth L. Immune Control of Legionella Infection: An in vivo Perspective |
title | Immune Control of Legionella Infection: An in vivo Perspective |
title_full | Immune Control of Legionella Infection: An in vivo Perspective |
title_fullStr | Immune Control of Legionella Infection: An in vivo Perspective |
title_full_unstemmed | Immune Control of Legionella Infection: An in vivo Perspective |
title_short | Immune Control of Legionella Infection: An in vivo Perspective |
title_sort | immune control of legionella infection: an in vivo perspective |
topic | Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3109619/ https://www.ncbi.nlm.nih.gov/pubmed/21687433 http://dx.doi.org/10.3389/fmicb.2011.00126 |
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