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Feasibility of Predicting MCI/AD Using Neuropsychological Tests and Serum β-Amyloid
We examined the usefulness of brief neuropsychological tests and serum Aβ as a predictive test for detecting MCI/AD in older adults. Serum Aβ levels were measured from 208 subjects who were cognitively normal at enrollment and blood draw. Twenty-eight of the subjects subsequently developed MCI (n =...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE-Hindawi Access to Research
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3109876/ https://www.ncbi.nlm.nih.gov/pubmed/21660215 http://dx.doi.org/10.4061/2011/786264 |
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author | Luis, Cheryl A. Abdullah, Laila Ait-Ghezala, Ghania Mouzon, Benoit Keegan, Andrew P. Crawford, Fiona Mullan, Michael |
author_facet | Luis, Cheryl A. Abdullah, Laila Ait-Ghezala, Ghania Mouzon, Benoit Keegan, Andrew P. Crawford, Fiona Mullan, Michael |
author_sort | Luis, Cheryl A. |
collection | PubMed |
description | We examined the usefulness of brief neuropsychological tests and serum Aβ as a predictive test for detecting MCI/AD in older adults. Serum Aβ levels were measured from 208 subjects who were cognitively normal at enrollment and blood draw. Twenty-eight of the subjects subsequently developed MCI (n = 18) or AD (n = 10) over the follow-up period. Baseline measures of global cognition, memory, language fluency, and serum Aβ(1–42) and the ratio of serum Aβ(1–42)/Aβ(1–40) were significant predictors for future MCI/AD using Cox regression with demographic variables, APOE ε4, vascular risk factors, and specific medication as covariates. An optimal sensitivity of 85.2% and specificity of 86.5% for predicting MCI/AD was achieved using ROC analyses. Brief neuropsychological tests and measurements of Aβ(1–42) obtained via blood warrants further study as a practical and cost effective method for wide-scale screening for identifying older adults who may be at-risk for pathological cognitive decline. |
format | Online Article Text |
id | pubmed-3109876 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | SAGE-Hindawi Access to Research |
record_format | MEDLINE/PubMed |
spelling | pubmed-31098762011-06-09 Feasibility of Predicting MCI/AD Using Neuropsychological Tests and Serum β-Amyloid Luis, Cheryl A. Abdullah, Laila Ait-Ghezala, Ghania Mouzon, Benoit Keegan, Andrew P. Crawford, Fiona Mullan, Michael Int J Alzheimers Dis Research Article We examined the usefulness of brief neuropsychological tests and serum Aβ as a predictive test for detecting MCI/AD in older adults. Serum Aβ levels were measured from 208 subjects who were cognitively normal at enrollment and blood draw. Twenty-eight of the subjects subsequently developed MCI (n = 18) or AD (n = 10) over the follow-up period. Baseline measures of global cognition, memory, language fluency, and serum Aβ(1–42) and the ratio of serum Aβ(1–42)/Aβ(1–40) were significant predictors for future MCI/AD using Cox regression with demographic variables, APOE ε4, vascular risk factors, and specific medication as covariates. An optimal sensitivity of 85.2% and specificity of 86.5% for predicting MCI/AD was achieved using ROC analyses. Brief neuropsychological tests and measurements of Aβ(1–42) obtained via blood warrants further study as a practical and cost effective method for wide-scale screening for identifying older adults who may be at-risk for pathological cognitive decline. SAGE-Hindawi Access to Research 2011-05-24 /pmc/articles/PMC3109876/ /pubmed/21660215 http://dx.doi.org/10.4061/2011/786264 Text en Copyright © 2011 Cheryl A. Luis et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Luis, Cheryl A. Abdullah, Laila Ait-Ghezala, Ghania Mouzon, Benoit Keegan, Andrew P. Crawford, Fiona Mullan, Michael Feasibility of Predicting MCI/AD Using Neuropsychological Tests and Serum β-Amyloid |
title | Feasibility of Predicting MCI/AD Using Neuropsychological Tests and Serum β-Amyloid |
title_full | Feasibility of Predicting MCI/AD Using Neuropsychological Tests and Serum β-Amyloid |
title_fullStr | Feasibility of Predicting MCI/AD Using Neuropsychological Tests and Serum β-Amyloid |
title_full_unstemmed | Feasibility of Predicting MCI/AD Using Neuropsychological Tests and Serum β-Amyloid |
title_short | Feasibility of Predicting MCI/AD Using Neuropsychological Tests and Serum β-Amyloid |
title_sort | feasibility of predicting mci/ad using neuropsychological tests and serum β-amyloid |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3109876/ https://www.ncbi.nlm.nih.gov/pubmed/21660215 http://dx.doi.org/10.4061/2011/786264 |
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