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The health status of Q-fever patients after long-term follow-up

BACKGROUND: In the Netherlands, from 2007 to 2009, 3,522 Q-fever cases were notified from three outbreaks. These are the largest documented outbreaks in the world. Previous studies suggest that symptoms can persist for a long period of time, resulting in a reduced quality of life (QoL). The aim of t...

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Autores principales: Morroy, Gabriëlla, Peters, Jeannette B, van Nieuwenhof, Malou, Bor, Hans HJ, Hautvast, Jeannine LA, van der Hoek, Wim, Wijkmans, Clementine J, Vercoulen, Jan H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3110112/
https://www.ncbi.nlm.nih.gov/pubmed/21501483
http://dx.doi.org/10.1186/1471-2334-11-97
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author Morroy, Gabriëlla
Peters, Jeannette B
van Nieuwenhof, Malou
Bor, Hans HJ
Hautvast, Jeannine LA
van der Hoek, Wim
Wijkmans, Clementine J
Vercoulen, Jan H
author_facet Morroy, Gabriëlla
Peters, Jeannette B
van Nieuwenhof, Malou
Bor, Hans HJ
Hautvast, Jeannine LA
van der Hoek, Wim
Wijkmans, Clementine J
Vercoulen, Jan H
author_sort Morroy, Gabriëlla
collection PubMed
description BACKGROUND: In the Netherlands, from 2007 to 2009, 3,522 Q-fever cases were notified from three outbreaks. These are the largest documented outbreaks in the world. Previous studies suggest that symptoms can persist for a long period of time, resulting in a reduced quality of life (QoL). The aim of this study was to qualify and quantify the health status of Q-fever patients after long-term follow-up. METHODS: 870 Q-fever patients of the 2007 and 2008 outbreaks were mailed a questionnaire 12 to 26 months after the onset of illness. We assessed demographic data and measured health status with the Nijmegen Clinical Screening Instrument (NCSI). The NCSI consists of three main domains of functional impairment, symptoms and QoL that are divided into eight sub-domains. The NCSI scores of Q-fever patients older than 50 years (N = 277) were compared with patients younger than 50 years (N = 238) and with norm data from healthy individuals (N = 65) and patients with chronic obstructive pulmonary disease (N = 128). RESULTS: The response rate was 65.7%. After applying exclusion criteria 515 Q-fever patients were included in this study. The long-term health status of two thirds of Q-fever patients (both younger and older than 50 years) was severely affected for at least one sub-domain. Patients scores were most severely affected on the sub-domains general QoL (44.9%) and fatigue (43.5%). Hospitalisation in the acute phase was significantly related to long-term behavioural impairment (OR 2.8, CI 1.5-5.1), poor health related QoL (OR 2.3,CI 1.5-4.0) and subjective symptoms (OR 1.9, CI 1.1-3.6). Lung or heart disease, depression and arthritis significantly affected the long-term health status of Q-fever patients. CONCLUSIONS: Q-fever patients presented 12 to 26 months after the onset of illness severe -clinically relevant- subjective symptoms, functional impairment and impaired QoL. All measured sub-domains of the health status were impaired. Hospitalisation and co-morbidity were predictors for worse scores. Our data emphasise that more attention is needed not only to prevent exposure to Q-fever but also for the prevention and treatment of the long-term consequences of this zoönosis.
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spelling pubmed-31101122011-06-08 The health status of Q-fever patients after long-term follow-up Morroy, Gabriëlla Peters, Jeannette B van Nieuwenhof, Malou Bor, Hans HJ Hautvast, Jeannine LA van der Hoek, Wim Wijkmans, Clementine J Vercoulen, Jan H BMC Infect Dis Research Article BACKGROUND: In the Netherlands, from 2007 to 2009, 3,522 Q-fever cases were notified from three outbreaks. These are the largest documented outbreaks in the world. Previous studies suggest that symptoms can persist for a long period of time, resulting in a reduced quality of life (QoL). The aim of this study was to qualify and quantify the health status of Q-fever patients after long-term follow-up. METHODS: 870 Q-fever patients of the 2007 and 2008 outbreaks were mailed a questionnaire 12 to 26 months after the onset of illness. We assessed demographic data and measured health status with the Nijmegen Clinical Screening Instrument (NCSI). The NCSI consists of three main domains of functional impairment, symptoms and QoL that are divided into eight sub-domains. The NCSI scores of Q-fever patients older than 50 years (N = 277) were compared with patients younger than 50 years (N = 238) and with norm data from healthy individuals (N = 65) and patients with chronic obstructive pulmonary disease (N = 128). RESULTS: The response rate was 65.7%. After applying exclusion criteria 515 Q-fever patients were included in this study. The long-term health status of two thirds of Q-fever patients (both younger and older than 50 years) was severely affected for at least one sub-domain. Patients scores were most severely affected on the sub-domains general QoL (44.9%) and fatigue (43.5%). Hospitalisation in the acute phase was significantly related to long-term behavioural impairment (OR 2.8, CI 1.5-5.1), poor health related QoL (OR 2.3,CI 1.5-4.0) and subjective symptoms (OR 1.9, CI 1.1-3.6). Lung or heart disease, depression and arthritis significantly affected the long-term health status of Q-fever patients. CONCLUSIONS: Q-fever patients presented 12 to 26 months after the onset of illness severe -clinically relevant- subjective symptoms, functional impairment and impaired QoL. All measured sub-domains of the health status were impaired. Hospitalisation and co-morbidity were predictors for worse scores. Our data emphasise that more attention is needed not only to prevent exposure to Q-fever but also for the prevention and treatment of the long-term consequences of this zoönosis. BioMed Central 2011-04-18 /pmc/articles/PMC3110112/ /pubmed/21501483 http://dx.doi.org/10.1186/1471-2334-11-97 Text en Copyright ©2011 Morroy et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Morroy, Gabriëlla
Peters, Jeannette B
van Nieuwenhof, Malou
Bor, Hans HJ
Hautvast, Jeannine LA
van der Hoek, Wim
Wijkmans, Clementine J
Vercoulen, Jan H
The health status of Q-fever patients after long-term follow-up
title The health status of Q-fever patients after long-term follow-up
title_full The health status of Q-fever patients after long-term follow-up
title_fullStr The health status of Q-fever patients after long-term follow-up
title_full_unstemmed The health status of Q-fever patients after long-term follow-up
title_short The health status of Q-fever patients after long-term follow-up
title_sort health status of q-fever patients after long-term follow-up
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3110112/
https://www.ncbi.nlm.nih.gov/pubmed/21501483
http://dx.doi.org/10.1186/1471-2334-11-97
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