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Association between Urinary Excretion of Cortisol and Markers of Oxidatively Damaged DNA and RNA in Humans
Chronic psychological stress is associated with accelerated aging, but the underlying biological mechanisms are not known. Prolonged elevations of the stress hormone cortisol is suspected to play a critical role. Through its actions, cortisol may potentially induce oxidatively generated damage to ce...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3110199/ https://www.ncbi.nlm.nih.gov/pubmed/21687734 http://dx.doi.org/10.1371/journal.pone.0020795 |
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author | Joergensen, Anders Broedbaek, Kasper Weimann, Allan Semba, Richard D. Ferrucci, Luigi Joergensen, Martin B. Poulsen, Henrik E. |
author_facet | Joergensen, Anders Broedbaek, Kasper Weimann, Allan Semba, Richard D. Ferrucci, Luigi Joergensen, Martin B. Poulsen, Henrik E. |
author_sort | Joergensen, Anders |
collection | PubMed |
description | Chronic psychological stress is associated with accelerated aging, but the underlying biological mechanisms are not known. Prolonged elevations of the stress hormone cortisol is suspected to play a critical role. Through its actions, cortisol may potentially induce oxidatively generated damage to cellular constituents such as DNA and RNA, a phenomenon which has been implicated in aging processes. We investigated the relationship between 24 h excretion of urinary cortisol and markers of oxidatively generated DNA and RNA damage, 8-oxo-7,8-dihydro-2′-deoxyguanosine and 8-oxo-7,8-dihydroguanosine, in a sample of 220 elderly men and women (age 65 – 83 years). We found a robust association between the excretion of cortisol and the oxidation markers (R(2) = 0.15, P<0.001 for both markers). Individuals in the highest quartile of cortisol excretion had a 57% and 61% higher median excretion of the DNA and RNA oxidation marker, respectively, than individuals in the lowest quartile. The finding adds support to the hypothesis that cortisol-induced damage to DNA/RNA is an explanatory factor in the complex relation between stress, aging and disease. |
format | Online Article Text |
id | pubmed-3110199 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-31101992011-06-16 Association between Urinary Excretion of Cortisol and Markers of Oxidatively Damaged DNA and RNA in Humans Joergensen, Anders Broedbaek, Kasper Weimann, Allan Semba, Richard D. Ferrucci, Luigi Joergensen, Martin B. Poulsen, Henrik E. PLoS One Research Article Chronic psychological stress is associated with accelerated aging, but the underlying biological mechanisms are not known. Prolonged elevations of the stress hormone cortisol is suspected to play a critical role. Through its actions, cortisol may potentially induce oxidatively generated damage to cellular constituents such as DNA and RNA, a phenomenon which has been implicated in aging processes. We investigated the relationship between 24 h excretion of urinary cortisol and markers of oxidatively generated DNA and RNA damage, 8-oxo-7,8-dihydro-2′-deoxyguanosine and 8-oxo-7,8-dihydroguanosine, in a sample of 220 elderly men and women (age 65 – 83 years). We found a robust association between the excretion of cortisol and the oxidation markers (R(2) = 0.15, P<0.001 for both markers). Individuals in the highest quartile of cortisol excretion had a 57% and 61% higher median excretion of the DNA and RNA oxidation marker, respectively, than individuals in the lowest quartile. The finding adds support to the hypothesis that cortisol-induced damage to DNA/RNA is an explanatory factor in the complex relation between stress, aging and disease. Public Library of Science 2011-06-07 /pmc/articles/PMC3110199/ /pubmed/21687734 http://dx.doi.org/10.1371/journal.pone.0020795 Text en Joergensen et al. https://creativecommons.org/publicdomain/zero/1.0/ This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. |
spellingShingle | Research Article Joergensen, Anders Broedbaek, Kasper Weimann, Allan Semba, Richard D. Ferrucci, Luigi Joergensen, Martin B. Poulsen, Henrik E. Association between Urinary Excretion of Cortisol and Markers of Oxidatively Damaged DNA and RNA in Humans |
title | Association between Urinary Excretion of Cortisol and Markers of Oxidatively Damaged DNA and RNA in Humans |
title_full | Association between Urinary Excretion of Cortisol and Markers of Oxidatively Damaged DNA and RNA in Humans |
title_fullStr | Association between Urinary Excretion of Cortisol and Markers of Oxidatively Damaged DNA and RNA in Humans |
title_full_unstemmed | Association between Urinary Excretion of Cortisol and Markers of Oxidatively Damaged DNA and RNA in Humans |
title_short | Association between Urinary Excretion of Cortisol and Markers of Oxidatively Damaged DNA and RNA in Humans |
title_sort | association between urinary excretion of cortisol and markers of oxidatively damaged dna and rna in humans |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3110199/ https://www.ncbi.nlm.nih.gov/pubmed/21687734 http://dx.doi.org/10.1371/journal.pone.0020795 |
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