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Both Stereoselective (R)- and (S)-1-Methyl-1,2,3,4-tetrahydroisoquinoline Enantiomers Protect Striatal Terminals Against Rotenone-Induced Suppression of Dopamine Release

1-Methyl-1,2,3,4-tetrahydroisoquinoline (1MeTIQ) is present in the human and rodent brain as a mixture of stereospecific (R)- and (S)-1MeTIQ enantiomers. The racemate, (R,S)-1MeTIQ, exhibits neuroprotective activity as shown in the earlier study by the authors, and In addition, it was suggested to p...

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Detalles Bibliográficos
Autores principales: Antkiewicz-Michaluk, Lucyna, Wąsik, Agnieszka, Romańska, Irena, Bojarski, Andrzej, Michaluk, Jerzy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3110269/
https://www.ncbi.nlm.nih.gov/pubmed/21069490
http://dx.doi.org/10.1007/s12640-010-9228-5

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