Repeat Blood Culture Positive for B. pseudomallei Indicates an Increased Risk of Death from Melioidosis

Melioidosis, a bacterial infection caused by Burkholderia pseudomallei, is notoriously difficult to cure despite appropriate antimicrobial therapy and has a mortality rate of up to 40%. We demonstrate that a blood culture positive for B. pseudomallei taken at the end of the first and/or second week...

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Detalles Bibliográficos
Autores principales: Limmathurotsakul, Direk, Wuthiekanun, Vanaporn, Wongsuvan, Gumphol, Pangmee, Sukanya, Amornchai, Premjit, Teparrakkul, Prapit, Teerawattanasook, Nittaya, Day, Nicholas P. J., Peacock, Sharon J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Tropical Medicine and Hygiene 2011
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3110378/
https://www.ncbi.nlm.nih.gov/pubmed/21633019
http://dx.doi.org/10.4269/ajtmh.2011.10-0618
Descripción
Sumario:Melioidosis, a bacterial infection caused by Burkholderia pseudomallei, is notoriously difficult to cure despite appropriate antimicrobial therapy and has a mortality rate of up to 40%. We demonstrate that a blood culture positive for B. pseudomallei taken at the end of the first and/or second week after hospitalization for melioidosis is a strong prognostic factor for death (adjusted odds ratio = 4.2, 95% confidence interval = 2.1–8.7, P < 0.001 and adjusted odds ratio = 2.6, 95% confidence interval = 1.1–6.0, P = 0.03, respectively). However, repeat cultures of respiratory secretions, urine, throat swabs, or pus/surface swabs provide no prognostic information. This finding highlights the need for follow-up blood cultures in patients with melioidosis.

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