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Role of salivary leukocyte protease inhibitor in periodontal disease progression

CONTEXT: Proteases play a major role in the tissue destruction involved in periodontal disease. It is known that the balance between proteases and their inhibitors is a major determinant in maintaining tissue integrity. The association between the proteases and periodontitis is well established, but...

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Autores principales: Pateel, Deepak, Seema, H., Kale, Akla
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3110464/
https://www.ncbi.nlm.nih.gov/pubmed/21691548
http://dx.doi.org/10.4103/0972-124X.70830
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author Pateel, Deepak
Seema, H.
Kale, Akla
author_facet Pateel, Deepak
Seema, H.
Kale, Akla
author_sort Pateel, Deepak
collection PubMed
description CONTEXT: Proteases play a major role in the tissue destruction involved in periodontal disease. It is known that the balance between proteases and their inhibitors is a major determinant in maintaining tissue integrity. The association between the proteases and periodontitis is well established, but not many studies have been carried out to know the role played by a protease inhibitor like salivary leukocyte protease inhibitor (SLPI) in periodontitis. AIM: The aim of the present study was to correlate SLPI with periodontitis. SETTINGS AND DESIGN: Case-control study. MATERIALS AND METHODS: Seventy-five clinically confirmed cases of periodontitis and 20 controls were included in the study. A detailed case history and periodontal index (PI) were recorded. Two milliliters of unstimulated saliva samples was obtained and subjected to quantification of SLPI leaves using SLPI in enzyme-linked immunosorbent assay (ELISA) kit. Based on the periodontal index score of the individuals, the cases and controls were divided into groups A, B and C, and the obtained SLPI levels were compared among the groups. STATISTICAL ANALYSIS: Mann-Whitney U test and correlation coefficient test. RESULTS: The results showed that in the initial stages of periodontitis there is a tendency of SLPI levels to be raised. The SLPI levels were found to be reduced in the terminal stages of periodontitis. CONCLUSION: It appears that SLPI accumulates in the local environment, at least in the initial stages of the periodontal disease, probably to inhibit the action of increased elastic activity.
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spelling pubmed-31104642011-06-20 Role of salivary leukocyte protease inhibitor in periodontal disease progression Pateel, Deepak Seema, H. Kale, Akla J Indian Soc Periodontol Original Article CONTEXT: Proteases play a major role in the tissue destruction involved in periodontal disease. It is known that the balance between proteases and their inhibitors is a major determinant in maintaining tissue integrity. The association between the proteases and periodontitis is well established, but not many studies have been carried out to know the role played by a protease inhibitor like salivary leukocyte protease inhibitor (SLPI) in periodontitis. AIM: The aim of the present study was to correlate SLPI with periodontitis. SETTINGS AND DESIGN: Case-control study. MATERIALS AND METHODS: Seventy-five clinically confirmed cases of periodontitis and 20 controls were included in the study. A detailed case history and periodontal index (PI) were recorded. Two milliliters of unstimulated saliva samples was obtained and subjected to quantification of SLPI leaves using SLPI in enzyme-linked immunosorbent assay (ELISA) kit. Based on the periodontal index score of the individuals, the cases and controls were divided into groups A, B and C, and the obtained SLPI levels were compared among the groups. STATISTICAL ANALYSIS: Mann-Whitney U test and correlation coefficient test. RESULTS: The results showed that in the initial stages of periodontitis there is a tendency of SLPI levels to be raised. The SLPI levels were found to be reduced in the terminal stages of periodontitis. CONCLUSION: It appears that SLPI accumulates in the local environment, at least in the initial stages of the periodontal disease, probably to inhibit the action of increased elastic activity. Medknow Publications 2010 /pmc/articles/PMC3110464/ /pubmed/21691548 http://dx.doi.org/10.4103/0972-124X.70830 Text en © Journal of Indian Society of Periodontology http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Pateel, Deepak
Seema, H.
Kale, Akla
Role of salivary leukocyte protease inhibitor in periodontal disease progression
title Role of salivary leukocyte protease inhibitor in periodontal disease progression
title_full Role of salivary leukocyte protease inhibitor in periodontal disease progression
title_fullStr Role of salivary leukocyte protease inhibitor in periodontal disease progression
title_full_unstemmed Role of salivary leukocyte protease inhibitor in periodontal disease progression
title_short Role of salivary leukocyte protease inhibitor in periodontal disease progression
title_sort role of salivary leukocyte protease inhibitor in periodontal disease progression
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3110464/
https://www.ncbi.nlm.nih.gov/pubmed/21691548
http://dx.doi.org/10.4103/0972-124X.70830
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