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Role of salivary leukocyte protease inhibitor in periodontal disease progression
CONTEXT: Proteases play a major role in the tissue destruction involved in periodontal disease. It is known that the balance between proteases and their inhibitors is a major determinant in maintaining tissue integrity. The association between the proteases and periodontitis is well established, but...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3110464/ https://www.ncbi.nlm.nih.gov/pubmed/21691548 http://dx.doi.org/10.4103/0972-124X.70830 |
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author | Pateel, Deepak Seema, H. Kale, Akla |
author_facet | Pateel, Deepak Seema, H. Kale, Akla |
author_sort | Pateel, Deepak |
collection | PubMed |
description | CONTEXT: Proteases play a major role in the tissue destruction involved in periodontal disease. It is known that the balance between proteases and their inhibitors is a major determinant in maintaining tissue integrity. The association between the proteases and periodontitis is well established, but not many studies have been carried out to know the role played by a protease inhibitor like salivary leukocyte protease inhibitor (SLPI) in periodontitis. AIM: The aim of the present study was to correlate SLPI with periodontitis. SETTINGS AND DESIGN: Case-control study. MATERIALS AND METHODS: Seventy-five clinically confirmed cases of periodontitis and 20 controls were included in the study. A detailed case history and periodontal index (PI) were recorded. Two milliliters of unstimulated saliva samples was obtained and subjected to quantification of SLPI leaves using SLPI in enzyme-linked immunosorbent assay (ELISA) kit. Based on the periodontal index score of the individuals, the cases and controls were divided into groups A, B and C, and the obtained SLPI levels were compared among the groups. STATISTICAL ANALYSIS: Mann-Whitney U test and correlation coefficient test. RESULTS: The results showed that in the initial stages of periodontitis there is a tendency of SLPI levels to be raised. The SLPI levels were found to be reduced in the terminal stages of periodontitis. CONCLUSION: It appears that SLPI accumulates in the local environment, at least in the initial stages of the periodontal disease, probably to inhibit the action of increased elastic activity. |
format | Online Article Text |
id | pubmed-3110464 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Medknow Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-31104642011-06-20 Role of salivary leukocyte protease inhibitor in periodontal disease progression Pateel, Deepak Seema, H. Kale, Akla J Indian Soc Periodontol Original Article CONTEXT: Proteases play a major role in the tissue destruction involved in periodontal disease. It is known that the balance between proteases and their inhibitors is a major determinant in maintaining tissue integrity. The association between the proteases and periodontitis is well established, but not many studies have been carried out to know the role played by a protease inhibitor like salivary leukocyte protease inhibitor (SLPI) in periodontitis. AIM: The aim of the present study was to correlate SLPI with periodontitis. SETTINGS AND DESIGN: Case-control study. MATERIALS AND METHODS: Seventy-five clinically confirmed cases of periodontitis and 20 controls were included in the study. A detailed case history and periodontal index (PI) were recorded. Two milliliters of unstimulated saliva samples was obtained and subjected to quantification of SLPI leaves using SLPI in enzyme-linked immunosorbent assay (ELISA) kit. Based on the periodontal index score of the individuals, the cases and controls were divided into groups A, B and C, and the obtained SLPI levels were compared among the groups. STATISTICAL ANALYSIS: Mann-Whitney U test and correlation coefficient test. RESULTS: The results showed that in the initial stages of periodontitis there is a tendency of SLPI levels to be raised. The SLPI levels were found to be reduced in the terminal stages of periodontitis. CONCLUSION: It appears that SLPI accumulates in the local environment, at least in the initial stages of the periodontal disease, probably to inhibit the action of increased elastic activity. Medknow Publications 2010 /pmc/articles/PMC3110464/ /pubmed/21691548 http://dx.doi.org/10.4103/0972-124X.70830 Text en © Journal of Indian Society of Periodontology http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Pateel, Deepak Seema, H. Kale, Akla Role of salivary leukocyte protease inhibitor in periodontal disease progression |
title | Role of salivary leukocyte protease inhibitor in periodontal disease progression |
title_full | Role of salivary leukocyte protease inhibitor in periodontal disease progression |
title_fullStr | Role of salivary leukocyte protease inhibitor in periodontal disease progression |
title_full_unstemmed | Role of salivary leukocyte protease inhibitor in periodontal disease progression |
title_short | Role of salivary leukocyte protease inhibitor in periodontal disease progression |
title_sort | role of salivary leukocyte protease inhibitor in periodontal disease progression |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3110464/ https://www.ncbi.nlm.nih.gov/pubmed/21691548 http://dx.doi.org/10.4103/0972-124X.70830 |
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