Cocos: Constructing multi-domain protein phylogenies

Phylogenies of multi-domain proteins have to incorporate macro-evolutionary events, which dramatically increases the complexity of their construction. We present an application to infer ancestral multi-domain proteins given a species tree and domain phylogenies. As the individual domain phylogenies...

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Autores principales: Homilius, Max, Wiedenhoeft, John, Thieme, Sebastian, Standfuß, Christoph, Kel, Ivan, Krause, Roland
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Tree of Life
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3110499/
https://www.ncbi.nlm.nih.gov/pubmed/21686311
http://dx.doi.org/10.1371/currents.RRN1240
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author Homilius, Max
Wiedenhoeft, John
Thieme, Sebastian
Standfuß, Christoph
Kel, Ivan
Krause, Roland
author_facet Homilius, Max
Wiedenhoeft, John
Thieme, Sebastian
Standfuß, Christoph
Kel, Ivan
Krause, Roland
author_sort Homilius, Max
collection PubMed
description Phylogenies of multi-domain proteins have to incorporate macro-evolutionary events, which dramatically increases the complexity of their construction. We present an application to infer ancestral multi-domain proteins given a species tree and domain phylogenies. As the individual domain phylogenies are often incongruent, we provide diagnostics for the identification and reconciliation of implausible topologies. We implement and extend a suggested algorithmic approach by Behzadi and Vingron (2006).
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spelling pubmed-31104992011-06-16 Cocos: Constructing multi-domain protein phylogenies Homilius, Max Wiedenhoeft, John Thieme, Sebastian Standfuß, Christoph Kel, Ivan Krause, Roland PLoS Curr Tree of Life Phylogenies of multi-domain proteins have to incorporate macro-evolutionary events, which dramatically increases the complexity of their construction. We present an application to infer ancestral multi-domain proteins given a species tree and domain phylogenies. As the individual domain phylogenies are often incongruent, we provide diagnostics for the identification and reconciliation of implausible topologies. We implement and extend a suggested algorithmic approach by Behzadi and Vingron (2006). Public Library of Science 2011-06-09 /pmc/articles/PMC3110499/ /pubmed/21686311 http://dx.doi.org/10.1371/currents.RRN1240 Text en http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Tree of Life
Homilius, Max
Wiedenhoeft, John
Thieme, Sebastian
Standfuß, Christoph
Kel, Ivan
Krause, Roland
Cocos: Constructing multi-domain protein phylogenies
title Cocos: Constructing multi-domain protein phylogenies
title_full Cocos: Constructing multi-domain protein phylogenies
title_fullStr Cocos: Constructing multi-domain protein phylogenies
title_full_unstemmed Cocos: Constructing multi-domain protein phylogenies
title_short Cocos: Constructing multi-domain protein phylogenies
title_sort cocos: constructing multi-domain protein phylogenies
topic Tree of Life
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3110499/
https://www.ncbi.nlm.nih.gov/pubmed/21686311
http://dx.doi.org/10.1371/currents.RRN1240
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AT standfußchristoph cocosconstructingmultidomainproteinphylogenies
AT kelivan cocosconstructingmultidomainproteinphylogenies
AT krauseroland cocosconstructingmultidomainproteinphylogenies

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