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Adeno-Associated Viral Vector-Mediated Transgene Expression Is Independent of DNA Methylation in Primate Liver and Skeletal Muscle

Recombinant adeno-associated viral (rAAV) vectors can support long-term transgene expression in quiescent tissues. Intramuscular (IM) administration of a single-stranded AAV vector (ssAAV) in the nonhuman primate (NHP) results in a peak protein level at 2–3 months, followed by a decrease over severa...

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Detalles Bibliográficos
Autores principales:	Léger, Adrien, Le Guiner, Caroline, Nickerson, Michael L., McGee Im, Kate, Ferry, Nicolas, Moullier, Philippe, Snyder, Richard O., Penaud-Budloo, Magalie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3110818/ https://www.ncbi.nlm.nih.gov/pubmed/21687632 http://dx.doi.org/10.1371/journal.pone.0020881

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