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Deoxyuridines from the Marine Sponge Associated Actinomycete Streptomyces microflavus

One new nucleoside derivative, named 3-acetyl-5-methyl-2′-deoxyuridine (1), along with two known compounds 3,5-dimethyl-2′-deoxyuridine (2) and 3-methyl-2′-deoxyuridine (3), were isolated from the cultures of Streptomyces microflavus. This strain was an associated actinomycete isolated from the mari...

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Detalles Bibliográficos
Autores principales: Li, Ke, Li, Qiao-Lian, Ji, Nai-Yun, Liu, Bo, Zhang, Wei, Cao, Xu-Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3111175/
https://www.ncbi.nlm.nih.gov/pubmed/21673882
http://dx.doi.org/10.3390/md9050690
Descripción
Sumario:One new nucleoside derivative, named 3-acetyl-5-methyl-2′-deoxyuridine (1), along with two known compounds 3,5-dimethyl-2′-deoxyuridine (2) and 3-methyl-2′-deoxyuridine (3), were isolated from the cultures of Streptomyces microflavus. This strain was an associated actinomycete isolated from the marine sponge Hymeniacidon perlevis collected from the coast of Dalian (China). Their structures were elucidated by detailed NMR and MS spectroscopic analysis as well as comparison with literature data.