Balticolid: A New 12-Membered Macrolide with Antiviral Activity from an Ascomycetous Fungus of Marine Origin

A new 12-membered macrolide, balticolid (1) was isolated from the EtOAc extract of the culture broth of fungal strain 222 belonging to the Ascomycota, which was found on driftwood collected from the coast of the Greifswalder Bodden, Baltic Sea, Germany. The structure of balticolid was determined to...

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Autores principales: Shushni, Muftah A. M., Singh, Rajinder, Mentel, Renate, Lindequist, Ulrike
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3111186/
https://www.ncbi.nlm.nih.gov/pubmed/21673893
http://dx.doi.org/10.3390/md9050844
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author Shushni, Muftah A. M.
Singh, Rajinder
Mentel, Renate
Lindequist, Ulrike
author_facet Shushni, Muftah A. M.
Singh, Rajinder
Mentel, Renate
Lindequist, Ulrike
author_sort Shushni, Muftah A. M.
collection PubMed
description A new 12-membered macrolide, balticolid (1) was isolated from the EtOAc extract of the culture broth of fungal strain 222 belonging to the Ascomycota, which was found on driftwood collected from the coast of the Greifswalder Bodden, Baltic Sea, Germany. The structure of balticolid was determined to be (3R,11R), (4E,8E)-3-hydroxy-11-methyloxacyclododeca-4,8-diene-1,7-dione using extensive spectral data as well as the modified Mosher ester method. Balticolid (1) displayed anti-HSV-1 activity with an IC(50) value of 0.45 μM.
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spelling pubmed-31111862011-06-13 Balticolid: A New 12-Membered Macrolide with Antiviral Activity from an Ascomycetous Fungus of Marine Origin Shushni, Muftah A. M. Singh, Rajinder Mentel, Renate Lindequist, Ulrike Mar Drugs Article A new 12-membered macrolide, balticolid (1) was isolated from the EtOAc extract of the culture broth of fungal strain 222 belonging to the Ascomycota, which was found on driftwood collected from the coast of the Greifswalder Bodden, Baltic Sea, Germany. The structure of balticolid was determined to be (3R,11R), (4E,8E)-3-hydroxy-11-methyloxacyclododeca-4,8-diene-1,7-dione using extensive spectral data as well as the modified Mosher ester method. Balticolid (1) displayed anti-HSV-1 activity with an IC(50) value of 0.45 μM. Molecular Diversity Preservation International 2011-05-13 /pmc/articles/PMC3111186/ /pubmed/21673893 http://dx.doi.org/10.3390/md9050844 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Shushni, Muftah A. M.
Singh, Rajinder
Mentel, Renate
Lindequist, Ulrike
Balticolid: A New 12-Membered Macrolide with Antiviral Activity from an Ascomycetous Fungus of Marine Origin
title Balticolid: A New 12-Membered Macrolide with Antiviral Activity from an Ascomycetous Fungus of Marine Origin
title_full Balticolid: A New 12-Membered Macrolide with Antiviral Activity from an Ascomycetous Fungus of Marine Origin
title_fullStr Balticolid: A New 12-Membered Macrolide with Antiviral Activity from an Ascomycetous Fungus of Marine Origin
title_full_unstemmed Balticolid: A New 12-Membered Macrolide with Antiviral Activity from an Ascomycetous Fungus of Marine Origin
title_short Balticolid: A New 12-Membered Macrolide with Antiviral Activity from an Ascomycetous Fungus of Marine Origin
title_sort balticolid: a new 12-membered macrolide with antiviral activity from an ascomycetous fungus of marine origin
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3111186/
https://www.ncbi.nlm.nih.gov/pubmed/21673893
http://dx.doi.org/10.3390/md9050844
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