Bioactive Indole Derivatives from the South Pacific Marine Sponges Rhopaloeides odorabile and Hyrtios sp.

Indole derivatives including bromoindoles have been isolated from the South Pacific marine sponges Rhopaloeides odorabile and Hyrtios sp. Their structures were established through analysis of mass spectra and 1D and 2D NMR spectroscopic data. Their potential inhibitory phospholipase A(2) (PLA(2)), a...

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Autores principales: Longeon, Arlette, Copp, Brent R., Quévrain, Elodie, Roué, Mélanie, Kientz, Betty, Cresteil, Thierry, Petek, Sylvain, Debitus, Cécile, Bourguet-Kondracki, Marie-Lise
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2011
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3111189/
https://www.ncbi.nlm.nih.gov/pubmed/21673896
http://dx.doi.org/10.3390/md9050879
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author Longeon, Arlette
Copp, Brent R.
Quévrain, Elodie
Roué, Mélanie
Kientz, Betty
Cresteil, Thierry
Petek, Sylvain
Debitus, Cécile
Bourguet-Kondracki, Marie-Lise
author_facet Longeon, Arlette
Copp, Brent R.
Quévrain, Elodie
Roué, Mélanie
Kientz, Betty
Cresteil, Thierry
Petek, Sylvain
Debitus, Cécile
Bourguet-Kondracki, Marie-Lise
author_sort Longeon, Arlette
collection PubMed
description Indole derivatives including bromoindoles have been isolated from the South Pacific marine sponges Rhopaloeides odorabile and Hyrtios sp. Their structures were established through analysis of mass spectra and 1D and 2D NMR spectroscopic data. Their potential inhibitory phospholipase A(2) (PLA(2)), antioxidant and cytotoxic activities were evaluated. The new derivative 5,6-dibromo-l-hypaphorine (9) isolated from Hyrtios sp. revealed a weak bee venom PLA(2) inhibition (IC(50) 0.2 mM) and a significant antioxidant activity with an Oxygen Radical Absorbance Capacity (ORAC) value of 0.22. The sesquiterpene aureol (4), also isolated from Hyrtios sp., showed the most potent antioxidant activity with an ORAC value of 0.29.
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spelling pubmed-31111892011-06-13 Bioactive Indole Derivatives from the South Pacific Marine Sponges Rhopaloeides odorabile and Hyrtios sp. Longeon, Arlette Copp, Brent R. Quévrain, Elodie Roué, Mélanie Kientz, Betty Cresteil, Thierry Petek, Sylvain Debitus, Cécile Bourguet-Kondracki, Marie-Lise Mar Drugs Article Indole derivatives including bromoindoles have been isolated from the South Pacific marine sponges Rhopaloeides odorabile and Hyrtios sp. Their structures were established through analysis of mass spectra and 1D and 2D NMR spectroscopic data. Their potential inhibitory phospholipase A(2) (PLA(2)), antioxidant and cytotoxic activities were evaluated. The new derivative 5,6-dibromo-l-hypaphorine (9) isolated from Hyrtios sp. revealed a weak bee venom PLA(2) inhibition (IC(50) 0.2 mM) and a significant antioxidant activity with an Oxygen Radical Absorbance Capacity (ORAC) value of 0.22. The sesquiterpene aureol (4), also isolated from Hyrtios sp., showed the most potent antioxidant activity with an ORAC value of 0.29. Molecular Diversity Preservation International 2011-05-24 /pmc/articles/PMC3111189/ /pubmed/21673896 http://dx.doi.org/10.3390/md9050879 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Longeon, Arlette
Copp, Brent R.
Quévrain, Elodie
Roué, Mélanie
Kientz, Betty
Cresteil, Thierry
Petek, Sylvain
Debitus, Cécile
Bourguet-Kondracki, Marie-Lise
Bioactive Indole Derivatives from the South Pacific Marine Sponges Rhopaloeides odorabile and Hyrtios sp.
title Bioactive Indole Derivatives from the South Pacific Marine Sponges Rhopaloeides odorabile and Hyrtios sp.
title_full Bioactive Indole Derivatives from the South Pacific Marine Sponges Rhopaloeides odorabile and Hyrtios sp.
title_fullStr Bioactive Indole Derivatives from the South Pacific Marine Sponges Rhopaloeides odorabile and Hyrtios sp.
title_full_unstemmed Bioactive Indole Derivatives from the South Pacific Marine Sponges Rhopaloeides odorabile and Hyrtios sp.
title_short Bioactive Indole Derivatives from the South Pacific Marine Sponges Rhopaloeides odorabile and Hyrtios sp.
title_sort bioactive indole derivatives from the south pacific marine sponges rhopaloeides odorabile and hyrtios sp.
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3111189/
https://www.ncbi.nlm.nih.gov/pubmed/21673896
http://dx.doi.org/10.3390/md9050879
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