Cargando…
Fatty acid desaturase (FADS) gene polymorphisms and insulin resistance in association with serum phospholipid polyunsaturated fatty acid composition in healthy Korean men: cross-sectional study
BACKGROUND: We investigated the relationship between fatty acid desaturase (FADS) gene polymorphisms and insulin resistance (IR) in association with serum phospholipid polyunsaturated fatty acid (FA) composition in healthy Korean men. METHODS: Healthy men (n = 576, 30 ~ 79 years old) were genotyped...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2011
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3111337/ https://www.ncbi.nlm.nih.gov/pubmed/21513558 http://dx.doi.org/10.1186/1743-7075-8-24 |
_version_ | 1782205606513344512 |
---|---|
author | Kim, Oh Yoen Lim, Hyo Hee Yang, Long In Chae, Jey Sook Lee, Jong Ho |
author_facet | Kim, Oh Yoen Lim, Hyo Hee Yang, Long In Chae, Jey Sook Lee, Jong Ho |
author_sort | Kim, Oh Yoen |
collection | PubMed |
description | BACKGROUND: We investigated the relationship between fatty acid desaturase (FADS) gene polymorphisms and insulin resistance (IR) in association with serum phospholipid polyunsaturated fatty acid (FA) composition in healthy Korean men. METHODS: Healthy men (n = 576, 30 ~ 79 years old) were genotyped for rs174537 near FADS1 (FEN1-10154G>T), FADS2 (rs174575C>G, rs2727270C>T), and FADS3 (rs1000778C>T) SNPs. Dietary intake, serum phospholipid FA composition and HOMA-IR were measured. RESULTS: Fasting insulin and HOMA-IR were significantly higher in the rs174575G allele carriers than the CC homozygotes, but lower in the rs2727270T allele carriers than the CC homozygotes. The proportion of linoleic acid (18:2ω-6, LA) was higher in the minor allele carriers of FEN1-10154G>T, rs174575C>G and rs2727270C>T than the major homozygotes, respectively. On the other hand, the proportions of dihomo-γ-linolenic acid (20:3ω-6, DGLA) and arachidonic acid (20:4ω-6, AA) in serum phospholipids were significantly lower in the minor allele carriers of FEN1-10154 G>T carriers and rs2727270C>T than the major homozygotes respectively. AA was also significantly lower in the rs1000778T allele carriers than the CC homozygotes. HOMA-IR positively correlated with LA and DGLA and negatively with AA/DGLA in total subjects. Interestingly, rs174575G allele carriers showed remarkably higher HOMA-IR than the CC homozygotes when subjects had higher proportions of DLGA (≥1.412% in total serum phospholipid FA composition) (P for interaction = 0.009) or of AA (≥4.573%) (P for interaction = 0.047). CONCLUSION: HOMA-IR is associated with FADS gene cluster as well as with FA composition in serum phospholipids. Additionally, HOMA-IR may be modulated by the interaction between rs174575C>G and the proportion of DGLA or AA in serum phospholipids. |
format | Online Article Text |
id | pubmed-3111337 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-31113372011-06-10 Fatty acid desaturase (FADS) gene polymorphisms and insulin resistance in association with serum phospholipid polyunsaturated fatty acid composition in healthy Korean men: cross-sectional study Kim, Oh Yoen Lim, Hyo Hee Yang, Long In Chae, Jey Sook Lee, Jong Ho Nutr Metab (Lond) Research BACKGROUND: We investigated the relationship between fatty acid desaturase (FADS) gene polymorphisms and insulin resistance (IR) in association with serum phospholipid polyunsaturated fatty acid (FA) composition in healthy Korean men. METHODS: Healthy men (n = 576, 30 ~ 79 years old) were genotyped for rs174537 near FADS1 (FEN1-10154G>T), FADS2 (rs174575C>G, rs2727270C>T), and FADS3 (rs1000778C>T) SNPs. Dietary intake, serum phospholipid FA composition and HOMA-IR were measured. RESULTS: Fasting insulin and HOMA-IR were significantly higher in the rs174575G allele carriers than the CC homozygotes, but lower in the rs2727270T allele carriers than the CC homozygotes. The proportion of linoleic acid (18:2ω-6, LA) was higher in the minor allele carriers of FEN1-10154G>T, rs174575C>G and rs2727270C>T than the major homozygotes, respectively. On the other hand, the proportions of dihomo-γ-linolenic acid (20:3ω-6, DGLA) and arachidonic acid (20:4ω-6, AA) in serum phospholipids were significantly lower in the minor allele carriers of FEN1-10154 G>T carriers and rs2727270C>T than the major homozygotes respectively. AA was also significantly lower in the rs1000778T allele carriers than the CC homozygotes. HOMA-IR positively correlated with LA and DGLA and negatively with AA/DGLA in total subjects. Interestingly, rs174575G allele carriers showed remarkably higher HOMA-IR than the CC homozygotes when subjects had higher proportions of DLGA (≥1.412% in total serum phospholipid FA composition) (P for interaction = 0.009) or of AA (≥4.573%) (P for interaction = 0.047). CONCLUSION: HOMA-IR is associated with FADS gene cluster as well as with FA composition in serum phospholipids. Additionally, HOMA-IR may be modulated by the interaction between rs174575C>G and the proportion of DGLA or AA in serum phospholipids. BioMed Central 2011-04-23 /pmc/articles/PMC3111337/ /pubmed/21513558 http://dx.doi.org/10.1186/1743-7075-8-24 Text en Copyright ©2011 Kim et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Kim, Oh Yoen Lim, Hyo Hee Yang, Long In Chae, Jey Sook Lee, Jong Ho Fatty acid desaturase (FADS) gene polymorphisms and insulin resistance in association with serum phospholipid polyunsaturated fatty acid composition in healthy Korean men: cross-sectional study |
title | Fatty acid desaturase (FADS) gene polymorphisms and insulin resistance in association with serum phospholipid polyunsaturated fatty acid composition in healthy Korean men: cross-sectional study |
title_full | Fatty acid desaturase (FADS) gene polymorphisms and insulin resistance in association with serum phospholipid polyunsaturated fatty acid composition in healthy Korean men: cross-sectional study |
title_fullStr | Fatty acid desaturase (FADS) gene polymorphisms and insulin resistance in association with serum phospholipid polyunsaturated fatty acid composition in healthy Korean men: cross-sectional study |
title_full_unstemmed | Fatty acid desaturase (FADS) gene polymorphisms and insulin resistance in association with serum phospholipid polyunsaturated fatty acid composition in healthy Korean men: cross-sectional study |
title_short | Fatty acid desaturase (FADS) gene polymorphisms and insulin resistance in association with serum phospholipid polyunsaturated fatty acid composition in healthy Korean men: cross-sectional study |
title_sort | fatty acid desaturase (fads) gene polymorphisms and insulin resistance in association with serum phospholipid polyunsaturated fatty acid composition in healthy korean men: cross-sectional study |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3111337/ https://www.ncbi.nlm.nih.gov/pubmed/21513558 http://dx.doi.org/10.1186/1743-7075-8-24 |
work_keys_str_mv | AT kimohyoen fattyaciddesaturasefadsgenepolymorphismsandinsulinresistanceinassociationwithserumphospholipidpolyunsaturatedfattyacidcompositioninhealthykoreanmencrosssectionalstudy AT limhyohee fattyaciddesaturasefadsgenepolymorphismsandinsulinresistanceinassociationwithserumphospholipidpolyunsaturatedfattyacidcompositioninhealthykoreanmencrosssectionalstudy AT yanglongin fattyaciddesaturasefadsgenepolymorphismsandinsulinresistanceinassociationwithserumphospholipidpolyunsaturatedfattyacidcompositioninhealthykoreanmencrosssectionalstudy AT chaejeysook fattyaciddesaturasefadsgenepolymorphismsandinsulinresistanceinassociationwithserumphospholipidpolyunsaturatedfattyacidcompositioninhealthykoreanmencrosssectionalstudy AT leejongho fattyaciddesaturasefadsgenepolymorphismsandinsulinresistanceinassociationwithserumphospholipidpolyunsaturatedfattyacidcompositioninhealthykoreanmencrosssectionalstudy |