A mutation in the dynein heavy chain gene compensates for energy deficit of mutant SOD1 mice and increases potentially neuroprotective IGF-1

BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by a progressive loss of motor neurons. ALS patients, as well as animal models such as mice overexpressing mutant SOD1s, are characterized by increased energy expenditure. In mice, this hypermetabolism...

Descripción completa

Detalles Bibliográficos
Autores principales: Fergani, Anissa, Eschbach, Judith, Oudart, Hugues, Larmet, Yves, Schwalenstocker, Birgit, Ludolph, Albert C, Loeffler, Jean-Philippe, Dupuis, Luc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3111394/
https://www.ncbi.nlm.nih.gov/pubmed/21521523
http://dx.doi.org/10.1186/1750-1326-6-26

Ejemplares similares

Ejemplares similares