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HLA Class I and Class II Associations in Dengue Viral Infections in a Sri Lankan Population

BACKGROUND: HLA class I and class II alleles have been shown to be associated with the development of dengue hemorrhagic fever (DHF)/dengue shock syndrome (DSS) in different populations. However, the majority of studies have been based on limited numbers of patients. In this study we aimed to invest...

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Autores principales: Malavige, Gathsaurie Neelika, Rostron, Tim, Rohanachandra, Lochana T., Jayaratne, S. D., Fernando, Neluka, De Silva, Aruna Dharshan, Liyanage, Malaka, Ogg, Graham
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3111420/
https://www.ncbi.nlm.nih.gov/pubmed/21694773
http://dx.doi.org/10.1371/journal.pone.0020581
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author Malavige, Gathsaurie Neelika
Rostron, Tim
Rohanachandra, Lochana T.
Jayaratne, S. D.
Fernando, Neluka
De Silva, Aruna Dharshan
Liyanage, Malaka
Ogg, Graham
author_facet Malavige, Gathsaurie Neelika
Rostron, Tim
Rohanachandra, Lochana T.
Jayaratne, S. D.
Fernando, Neluka
De Silva, Aruna Dharshan
Liyanage, Malaka
Ogg, Graham
author_sort Malavige, Gathsaurie Neelika
collection PubMed
description BACKGROUND: HLA class I and class II alleles have been shown to be associated with the development of dengue hemorrhagic fever (DHF)/dengue shock syndrome (DSS) in different populations. However, the majority of studies have been based on limited numbers of patients. In this study we aimed to investigate the HLA-class I and class II alleles that are positively and negatively associated with the development of DSS in a cohort of patients with DHF and also the alleles associated with development of DHF during primary dengue infections in a Sri Lankan population. METHODOLOGY/PRINCIPAL FINDINGS: The allele frequencies of HLA class I and class II alleles were compared in 110 patients with DHF and 119 individuals from the population who had never reported a symptomatic dengue infection at the time of recruitment. We found that HLA-A*31 (corrected P = 0.01) and DRB1*08 (corrected P = 0.009) were associated with susceptibility to DSS when infected with the dengue virus, during secondary dengue infection. The frequency of DRB1*08 allele was 28.7 times higher than in the normal population in patients with DSS. HLA-A*31 allele was increased 16.6 fold in DHF who developed shock when compared to those who did not develop shock. A*24 (corrected P = 0.03) and DRB1*12 (corrected P = 0.041) were strongly associated with the development of DHF during primary dengue infection. CONCLUSIONS/SIGNIFICANCE: These data suggest that certain HLA alleles confer susceptibility/protection to severe dengue infections. As T cell epitope recognition depend on the HLA type of an individual, it would be now important to investigate how epitope specific T cells associate with primary and secondary dengue infections and in severe dengue infections.
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spelling pubmed-31114202011-06-21 HLA Class I and Class II Associations in Dengue Viral Infections in a Sri Lankan Population Malavige, Gathsaurie Neelika Rostron, Tim Rohanachandra, Lochana T. Jayaratne, S. D. Fernando, Neluka De Silva, Aruna Dharshan Liyanage, Malaka Ogg, Graham PLoS One Research Article BACKGROUND: HLA class I and class II alleles have been shown to be associated with the development of dengue hemorrhagic fever (DHF)/dengue shock syndrome (DSS) in different populations. However, the majority of studies have been based on limited numbers of patients. In this study we aimed to investigate the HLA-class I and class II alleles that are positively and negatively associated with the development of DSS in a cohort of patients with DHF and also the alleles associated with development of DHF during primary dengue infections in a Sri Lankan population. METHODOLOGY/PRINCIPAL FINDINGS: The allele frequencies of HLA class I and class II alleles were compared in 110 patients with DHF and 119 individuals from the population who had never reported a symptomatic dengue infection at the time of recruitment. We found that HLA-A*31 (corrected P = 0.01) and DRB1*08 (corrected P = 0.009) were associated with susceptibility to DSS when infected with the dengue virus, during secondary dengue infection. The frequency of DRB1*08 allele was 28.7 times higher than in the normal population in patients with DSS. HLA-A*31 allele was increased 16.6 fold in DHF who developed shock when compared to those who did not develop shock. A*24 (corrected P = 0.03) and DRB1*12 (corrected P = 0.041) were strongly associated with the development of DHF during primary dengue infection. CONCLUSIONS/SIGNIFICANCE: These data suggest that certain HLA alleles confer susceptibility/protection to severe dengue infections. As T cell epitope recognition depend on the HLA type of an individual, it would be now important to investigate how epitope specific T cells associate with primary and secondary dengue infections and in severe dengue infections. Public Library of Science 2011-06-09 /pmc/articles/PMC3111420/ /pubmed/21694773 http://dx.doi.org/10.1371/journal.pone.0020581 Text en Malavige et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Malavige, Gathsaurie Neelika
Rostron, Tim
Rohanachandra, Lochana T.
Jayaratne, S. D.
Fernando, Neluka
De Silva, Aruna Dharshan
Liyanage, Malaka
Ogg, Graham
HLA Class I and Class II Associations in Dengue Viral Infections in a Sri Lankan Population
title HLA Class I and Class II Associations in Dengue Viral Infections in a Sri Lankan Population
title_full HLA Class I and Class II Associations in Dengue Viral Infections in a Sri Lankan Population
title_fullStr HLA Class I and Class II Associations in Dengue Viral Infections in a Sri Lankan Population
title_full_unstemmed HLA Class I and Class II Associations in Dengue Viral Infections in a Sri Lankan Population
title_short HLA Class I and Class II Associations in Dengue Viral Infections in a Sri Lankan Population
title_sort hla class i and class ii associations in dengue viral infections in a sri lankan population
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3111420/
https://www.ncbi.nlm.nih.gov/pubmed/21694773
http://dx.doi.org/10.1371/journal.pone.0020581
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