IL8 and Cathepsin B as Melanoma Serum Biomarkers

Melanoma accounts for only a small portion of skin cancer but it is associated with high mortality. Melanoma serum biomarkers that may aid early diagnosis or guide therapy are needed clinically. However, studies of serum biomarkers have often been hampered by the serum interference that causes false...

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Detalles Bibliográficos
Autores principales: Zhang, Hongtao, Fu, Ting, McGettigan, Suzanne, Kumar, Suresh, Liu, Shujing, Speicher, David, Schuchter, Lynn, Xu, Xiaowei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3111615/
https://www.ncbi.nlm.nih.gov/pubmed/21673904
http://dx.doi.org/10.3390/ijms12031505
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author Zhang, Hongtao
Fu, Ting
McGettigan, Suzanne
Kumar, Suresh
Liu, Shujing
Speicher, David
Schuchter, Lynn
Xu, Xiaowei
author_facet Zhang, Hongtao
Fu, Ting
McGettigan, Suzanne
Kumar, Suresh
Liu, Shujing
Speicher, David
Schuchter, Lynn
Xu, Xiaowei
author_sort Zhang, Hongtao
collection PubMed
description Melanoma accounts for only a small portion of skin cancer but it is associated with high mortality. Melanoma serum biomarkers that may aid early diagnosis or guide therapy are needed clinically. However, studies of serum biomarkers have often been hampered by the serum interference that causes false readouts in immunological tests. Here we show that, after using a special buffer to eliminate the serum interference, IL-8 and cathepsin B levels were significantly elevated in melanoma patients (p < 0.05). More importantly, the combination of IL-8 and cathepsin B were also studied as a prognosis marker for melanoma mortality. Our study provides a novel approach to examine serum biomarkers.
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spelling pubmed-31116152011-06-13 IL8 and Cathepsin B as Melanoma Serum Biomarkers Zhang, Hongtao Fu, Ting McGettigan, Suzanne Kumar, Suresh Liu, Shujing Speicher, David Schuchter, Lynn Xu, Xiaowei Int J Mol Sci Article Melanoma accounts for only a small portion of skin cancer but it is associated with high mortality. Melanoma serum biomarkers that may aid early diagnosis or guide therapy are needed clinically. However, studies of serum biomarkers have often been hampered by the serum interference that causes false readouts in immunological tests. Here we show that, after using a special buffer to eliminate the serum interference, IL-8 and cathepsin B levels were significantly elevated in melanoma patients (p < 0.05). More importantly, the combination of IL-8 and cathepsin B were also studied as a prognosis marker for melanoma mortality. Our study provides a novel approach to examine serum biomarkers. Molecular Diversity Preservation International (MDPI) 2011-02-25 /pmc/articles/PMC3111615/ /pubmed/21673904 http://dx.doi.org/10.3390/ijms12031505 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Zhang, Hongtao
Fu, Ting
McGettigan, Suzanne
Kumar, Suresh
Liu, Shujing
Speicher, David
Schuchter, Lynn
Xu, Xiaowei
IL8 and Cathepsin B as Melanoma Serum Biomarkers
title IL8 and Cathepsin B as Melanoma Serum Biomarkers
title_full IL8 and Cathepsin B as Melanoma Serum Biomarkers
title_fullStr IL8 and Cathepsin B as Melanoma Serum Biomarkers
title_full_unstemmed IL8 and Cathepsin B as Melanoma Serum Biomarkers
title_short IL8 and Cathepsin B as Melanoma Serum Biomarkers
title_sort il8 and cathepsin b as melanoma serum biomarkers
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3111615/
https://www.ncbi.nlm.nih.gov/pubmed/21673904
http://dx.doi.org/10.3390/ijms12031505
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