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Combined 3D-QSAR Modeling and Molecular Docking Studies on Pyrrole-Indolin-2-ones as Aurora A Kinase Inhibitors

Aurora kinases have emerged as attractive targets for the design of anticancer drugs. 3D-QSAR (comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA)) and Surflex-docking studies were performed on a series of pyrrole-indoline-2-ones as Aurora A in...

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Detalles Bibliográficos
Autores principales:	Ai, Yong, Wang, Shao-Teng, Sun, Ping-Hua, Song, Fa-Jun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Molecular Diversity Preservation International (MDPI) 2011
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3111621/ https://www.ncbi.nlm.nih.gov/pubmed/21673910 http://dx.doi.org/10.3390/ijms12031605

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