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Secondary metabolites and bioactivities of Myrtus communis
BACKGROUND: Myrtus species are characterized by the presence of phenolic acids, flavonoids, tannins, volatile oils and fatty acids. They are remedies for variety of ailments. This study therefore investigated medicinal effects of Myrtus communis L. METHODS: Bioactivity studies of Myrtus communis L....
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3111689/ https://www.ncbi.nlm.nih.gov/pubmed/21713133 http://dx.doi.org/10.4103/0974-8490.75449 |
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author | Nassar, Mahmoud I. Aboutabl, El-Sayed A. Ahmed, Rania F. El-Khrisy, Ezzel-Din A. Ibrahim, Khaled M. Sleem, Amany A. |
author_facet | Nassar, Mahmoud I. Aboutabl, El-Sayed A. Ahmed, Rania F. El-Khrisy, Ezzel-Din A. Ibrahim, Khaled M. Sleem, Amany A. |
author_sort | Nassar, Mahmoud I. |
collection | PubMed |
description | BACKGROUND: Myrtus species are characterized by the presence of phenolic acids, flavonoids, tannins, volatile oils and fatty acids. They are remedies for variety of ailments. This study therefore investigated medicinal effects of Myrtus communis L. METHODS: Bioactivity studies of Myrtus communis L. leaves were carried out on volatile oil, 7% methanol and aqueous extracts and the isolated compounds myricetin 3-O-β-glucopyranoside, myricetin 3-O-∝–rhamnopyranoside and gallic acid. RESULTS: Determination of the median lethal dose (LD(50)) revealed that the volatile oil, alcoholic and aqueous extracts were practically nontoxic and highly safe as no lethality was observed. The tested materials (volatile oil, alcoholic and aqueous extracts, myricetin 3-O-β-glucopyranoside, myricetin 3-O-∝–rhamnopyranoside and gallic acid) showed significant antihyperglycemic, anti-inflammatory and antinociceptive effects as compared with control groups and reference drugs. CONCLUSION: Administration of extracts of M. communis leaves could be safe at the dose used in this study. |
format | Online Article Text |
id | pubmed-3111689 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Medknow Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-31116892011-06-27 Secondary metabolites and bioactivities of Myrtus communis Nassar, Mahmoud I. Aboutabl, El-Sayed A. Ahmed, Rania F. El-Khrisy, Ezzel-Din A. Ibrahim, Khaled M. Sleem, Amany A. Pharmacognosy Res Original Article BACKGROUND: Myrtus species are characterized by the presence of phenolic acids, flavonoids, tannins, volatile oils and fatty acids. They are remedies for variety of ailments. This study therefore investigated medicinal effects of Myrtus communis L. METHODS: Bioactivity studies of Myrtus communis L. leaves were carried out on volatile oil, 7% methanol and aqueous extracts and the isolated compounds myricetin 3-O-β-glucopyranoside, myricetin 3-O-∝–rhamnopyranoside and gallic acid. RESULTS: Determination of the median lethal dose (LD(50)) revealed that the volatile oil, alcoholic and aqueous extracts were practically nontoxic and highly safe as no lethality was observed. The tested materials (volatile oil, alcoholic and aqueous extracts, myricetin 3-O-β-glucopyranoside, myricetin 3-O-∝–rhamnopyranoside and gallic acid) showed significant antihyperglycemic, anti-inflammatory and antinociceptive effects as compared with control groups and reference drugs. CONCLUSION: Administration of extracts of M. communis leaves could be safe at the dose used in this study. Medknow Publications 2010 /pmc/articles/PMC3111689/ /pubmed/21713133 http://dx.doi.org/10.4103/0974-8490.75449 Text en © Pharmacognosy Research http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Nassar, Mahmoud I. Aboutabl, El-Sayed A. Ahmed, Rania F. El-Khrisy, Ezzel-Din A. Ibrahim, Khaled M. Sleem, Amany A. Secondary metabolites and bioactivities of Myrtus communis |
title | Secondary metabolites and bioactivities of Myrtus communis |
title_full | Secondary metabolites and bioactivities of Myrtus communis |
title_fullStr | Secondary metabolites and bioactivities of Myrtus communis |
title_full_unstemmed | Secondary metabolites and bioactivities of Myrtus communis |
title_short | Secondary metabolites and bioactivities of Myrtus communis |
title_sort | secondary metabolites and bioactivities of myrtus communis |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3111689/ https://www.ncbi.nlm.nih.gov/pubmed/21713133 http://dx.doi.org/10.4103/0974-8490.75449 |
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