Modulating effect of Gmelina arborea Linn. on immunosuppressed albino rats

AIM: In the present study, the immunomodulatory effects of roots of Gmelina arborea Linn. were investigated MATERIALS AND METHODS: Methanolic extract of G. arborea Linn. (MEGA) and its ethyl acetate fraction (EAFME) were used for evaluating the pharmacological activity. The modulating effect was eva...

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Detalles Bibliográficos
Autores principales: Shukla, S. H., Saluja, A. K., Pandya, S. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications 2010
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3111695/
https://www.ncbi.nlm.nih.gov/pubmed/21713139
http://dx.doi.org/10.4103/0974-8490.75455
Descripción
Sumario:AIM: In the present study, the immunomodulatory effects of roots of Gmelina arborea Linn. were investigated MATERIALS AND METHODS: Methanolic extract of G. arborea Linn. (MEGA) and its ethyl acetate fraction (EAFME) were used for evaluating the pharmacological activity. The modulating effect was evaluated on humoral and cell-mediated immune response using animal models like cyclophosphamide-induced myelosuppression, delayed-type hypersensitivity (DTH) response, and humoral antibody (HA) titre RESULTS: Both test extracts produced significant increase in HA titre, DTH response, and levels of total white blood cell count CONCLUSION: This drug is found to be a potential immunostimulant

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