Modulating effect of Gmelina arborea Linn. on immunosuppressed albino rats

AIM: In the present study, the immunomodulatory effects of roots of Gmelina arborea Linn. were investigated MATERIALS AND METHODS: Methanolic extract of G. arborea Linn. (MEGA) and its ethyl acetate fraction (EAFME) were used for evaluating the pharmacological activity. The modulating effect was eva...

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Detalles Bibliográficos
Autores principales: Shukla, S. H., Saluja, A. K., Pandya, S. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications 2010
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3111695/
https://www.ncbi.nlm.nih.gov/pubmed/21713139
http://dx.doi.org/10.4103/0974-8490.75455
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author Shukla, S. H.
Saluja, A. K.
Pandya, S. S.
author_facet Shukla, S. H.
Saluja, A. K.
Pandya, S. S.
author_sort Shukla, S. H.
collection PubMed
description AIM: In the present study, the immunomodulatory effects of roots of Gmelina arborea Linn. were investigated MATERIALS AND METHODS: Methanolic extract of G. arborea Linn. (MEGA) and its ethyl acetate fraction (EAFME) were used for evaluating the pharmacological activity. The modulating effect was evaluated on humoral and cell-mediated immune response using animal models like cyclophosphamide-induced myelosuppression, delayed-type hypersensitivity (DTH) response, and humoral antibody (HA) titre RESULTS: Both test extracts produced significant increase in HA titre, DTH response, and levels of total white blood cell count CONCLUSION: This drug is found to be a potential immunostimulant
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spelling pubmed-31116952011-06-27 Modulating effect of Gmelina arborea Linn. on immunosuppressed albino rats Shukla, S. H. Saluja, A. K. Pandya, S. S. Pharmacognosy Res Original Article AIM: In the present study, the immunomodulatory effects of roots of Gmelina arborea Linn. were investigated MATERIALS AND METHODS: Methanolic extract of G. arborea Linn. (MEGA) and its ethyl acetate fraction (EAFME) were used for evaluating the pharmacological activity. The modulating effect was evaluated on humoral and cell-mediated immune response using animal models like cyclophosphamide-induced myelosuppression, delayed-type hypersensitivity (DTH) response, and humoral antibody (HA) titre RESULTS: Both test extracts produced significant increase in HA titre, DTH response, and levels of total white blood cell count CONCLUSION: This drug is found to be a potential immunostimulant Medknow Publications 2010 /pmc/articles/PMC3111695/ /pubmed/21713139 http://dx.doi.org/10.4103/0974-8490.75455 Text en © Pharmacognosy Research http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Shukla, S. H.
Saluja, A. K.
Pandya, S. S.
Modulating effect of Gmelina arborea Linn. on immunosuppressed albino rats
title Modulating effect of Gmelina arborea Linn. on immunosuppressed albino rats
title_full Modulating effect of Gmelina arborea Linn. on immunosuppressed albino rats
title_fullStr Modulating effect of Gmelina arborea Linn. on immunosuppressed albino rats
title_full_unstemmed Modulating effect of Gmelina arborea Linn. on immunosuppressed albino rats
title_short Modulating effect of Gmelina arborea Linn. on immunosuppressed albino rats
title_sort modulating effect of gmelina arborea linn. on immunosuppressed albino rats
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3111695/
https://www.ncbi.nlm.nih.gov/pubmed/21713139
http://dx.doi.org/10.4103/0974-8490.75455
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